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Rare anaplastic sarcoma of the kidney: A case report
BACKGROUND: Anaplastic sarcoma of the kidney (ASK) is a rare and newly recognized renal neoplasm. The tumor usually is extensive and cystic, characterized by pleomorphic spindle cells with marked atypia and associated with multinucleated cells. To date, only 27 cases have been reported in the litera...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190953/ https://www.ncbi.nlm.nih.gov/pubmed/32368542 http://dx.doi.org/10.12998/wjcc.v8.i8.1495 |
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author | Kao, Jsun-Liang Tsung, Swei-Hsiung Shiao, Chih-Chung |
author_facet | Kao, Jsun-Liang Tsung, Swei-Hsiung Shiao, Chih-Chung |
author_sort | Kao, Jsun-Liang |
collection | PubMed |
description | BACKGROUND: Anaplastic sarcoma of the kidney (ASK) is a rare and newly recognized renal neoplasm. The tumor usually is extensive and cystic, characterized by pleomorphic spindle cells with marked atypia and associated with multinucleated cells. To date, only 27 cases have been reported in the literature. The authors present an additional case and summarize the relevant knowledge in the literature. CASE SUMMARY: A 27-year-old previously healthy woman presented with a palpable mass over the abdomen and right flank soreness for one year. After the computed tomography study, the patient underwent right radical nephrectomy obtaining a 1680-g tumor with a size of 18.4 cm × 14.5 cm × 11 cm. The tumor is chiefly composed of anaplastic spindle cells with marked nuclear atypia admixed with multinucleated cells. Immunohistochemical evaluation of tumor cells exhibited diffuse positivity for CD56, p53, and vimentin, and focally positive for desmin. The diagnosis of ASK was established. Unfortunately, a local tumor recurrence followed by a distant metastasis developed within months. The patient died 26 months after the initial surgery. Comparing to the previously 27 cases of ASK, the current case had a relatively worse prognosis, which might be potentially associated with older patient age, larger tumor size, and the lack of en-bloc resection of adjacent organs during the initial radical nephrectomy. CONCLUSION: This case points out the featured pathological findings for diagnosing ASK and suggests more aggressive management for patients with ASK. |
format | Online Article Text |
id | pubmed-7190953 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-71909532020-05-04 Rare anaplastic sarcoma of the kidney: A case report Kao, Jsun-Liang Tsung, Swei-Hsiung Shiao, Chih-Chung World J Clin Cases Case Report BACKGROUND: Anaplastic sarcoma of the kidney (ASK) is a rare and newly recognized renal neoplasm. The tumor usually is extensive and cystic, characterized by pleomorphic spindle cells with marked atypia and associated with multinucleated cells. To date, only 27 cases have been reported in the literature. The authors present an additional case and summarize the relevant knowledge in the literature. CASE SUMMARY: A 27-year-old previously healthy woman presented with a palpable mass over the abdomen and right flank soreness for one year. After the computed tomography study, the patient underwent right radical nephrectomy obtaining a 1680-g tumor with a size of 18.4 cm × 14.5 cm × 11 cm. The tumor is chiefly composed of anaplastic spindle cells with marked nuclear atypia admixed with multinucleated cells. Immunohistochemical evaluation of tumor cells exhibited diffuse positivity for CD56, p53, and vimentin, and focally positive for desmin. The diagnosis of ASK was established. Unfortunately, a local tumor recurrence followed by a distant metastasis developed within months. The patient died 26 months after the initial surgery. Comparing to the previously 27 cases of ASK, the current case had a relatively worse prognosis, which might be potentially associated with older patient age, larger tumor size, and the lack of en-bloc resection of adjacent organs during the initial radical nephrectomy. CONCLUSION: This case points out the featured pathological findings for diagnosing ASK and suggests more aggressive management for patients with ASK. Baishideng Publishing Group Inc 2020-04-26 2020-04-26 /pmc/articles/PMC7190953/ /pubmed/32368542 http://dx.doi.org/10.12998/wjcc.v8.i8.1495 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Case Report Kao, Jsun-Liang Tsung, Swei-Hsiung Shiao, Chih-Chung Rare anaplastic sarcoma of the kidney: A case report |
title | Rare anaplastic sarcoma of the kidney: A case report |
title_full | Rare anaplastic sarcoma of the kidney: A case report |
title_fullStr | Rare anaplastic sarcoma of the kidney: A case report |
title_full_unstemmed | Rare anaplastic sarcoma of the kidney: A case report |
title_short | Rare anaplastic sarcoma of the kidney: A case report |
title_sort | rare anaplastic sarcoma of the kidney: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190953/ https://www.ncbi.nlm.nih.gov/pubmed/32368542 http://dx.doi.org/10.12998/wjcc.v8.i8.1495 |
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