Cargando…
Zinc and Its Transporters in Epigenetics
Epigenetic events like DNA methylation and histone modification can alter heritable phenotypes. Zinc is required for the activity of various epigenetic enzymes, such as DNA methyltransferases (DNMTs), histone acetyltransferases (HATs), histone deacetylases (HDACs), and histone demethylases, which po...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Molecular and Cellular Biology
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191051/ https://www.ncbi.nlm.nih.gov/pubmed/32274919 http://dx.doi.org/10.14348/molcells.2020.0026 |
_version_ | 1783527798978117632 |
---|---|
author | Brito, Sofia Lee, Mi-Gi Bin, Bum-Ho Lee, Jong-Soo |
author_facet | Brito, Sofia Lee, Mi-Gi Bin, Bum-Ho Lee, Jong-Soo |
author_sort | Brito, Sofia |
collection | PubMed |
description | Epigenetic events like DNA methylation and histone modification can alter heritable phenotypes. Zinc is required for the activity of various epigenetic enzymes, such as DNA methyltransferases (DNMTs), histone acetyltransferases (HATs), histone deacetylases (HDACs), and histone demethylases, which possess several zinc binding sites. Thus, the dysregulation of zinc homeostasis can lead to epigenetic alterations. Zinc homeostasis is regulated by Zinc Transporters (ZnTs), Zrt- and Irt-like proteins (ZIPs), and the zinc storage protein metallothionein (MT). Recent advances revealed that ZIPs modulate epigenetics. ZIP10 deficiency was found to result in reduced HATs, confirming its involvement in histone acetylation for rigid skin barrier formation. ZIP13 deficiency, which is associated with Spondylocheirodysplastic Ehlers-Danlos syndrome (SCD-EDS), increases DNMT activity, leading to dysgenesis of dermis via improper gene expressions. However, the precise molecular mechanisms remain to be elucidated. Future molecular studies investigating the involvement of zinc and its transporters in epigenetics are warranted. |
format | Online Article Text |
id | pubmed-7191051 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Korean Society for Molecular and Cellular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-71910512020-05-11 Zinc and Its Transporters in Epigenetics Brito, Sofia Lee, Mi-Gi Bin, Bum-Ho Lee, Jong-Soo Mol Cells Minireview Epigenetic events like DNA methylation and histone modification can alter heritable phenotypes. Zinc is required for the activity of various epigenetic enzymes, such as DNA methyltransferases (DNMTs), histone acetyltransferases (HATs), histone deacetylases (HDACs), and histone demethylases, which possess several zinc binding sites. Thus, the dysregulation of zinc homeostasis can lead to epigenetic alterations. Zinc homeostasis is regulated by Zinc Transporters (ZnTs), Zrt- and Irt-like proteins (ZIPs), and the zinc storage protein metallothionein (MT). Recent advances revealed that ZIPs modulate epigenetics. ZIP10 deficiency was found to result in reduced HATs, confirming its involvement in histone acetylation for rigid skin barrier formation. ZIP13 deficiency, which is associated with Spondylocheirodysplastic Ehlers-Danlos syndrome (SCD-EDS), increases DNMT activity, leading to dysgenesis of dermis via improper gene expressions. However, the precise molecular mechanisms remain to be elucidated. Future molecular studies investigating the involvement of zinc and its transporters in epigenetics are warranted. Korean Society for Molecular and Cellular Biology 2020-04-30 2020-04-10 /pmc/articles/PMC7191051/ /pubmed/32274919 http://dx.doi.org/10.14348/molcells.2020.0026 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Minireview Brito, Sofia Lee, Mi-Gi Bin, Bum-Ho Lee, Jong-Soo Zinc and Its Transporters in Epigenetics |
title | Zinc and Its Transporters in Epigenetics |
title_full | Zinc and Its Transporters in Epigenetics |
title_fullStr | Zinc and Its Transporters in Epigenetics |
title_full_unstemmed | Zinc and Its Transporters in Epigenetics |
title_short | Zinc and Its Transporters in Epigenetics |
title_sort | zinc and its transporters in epigenetics |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191051/ https://www.ncbi.nlm.nih.gov/pubmed/32274919 http://dx.doi.org/10.14348/molcells.2020.0026 |
work_keys_str_mv | AT britosofia zincanditstransportersinepigenetics AT leemigi zincanditstransportersinepigenetics AT binbumho zincanditstransportersinepigenetics AT leejongsoo zincanditstransportersinepigenetics |