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Association Between Steno-Occlusive Middle Cerebral Artery and Basal Ganglia Perivascular Spaces

Objectives: Enlarged perivascular spaces in the basal ganglia (BG-EPVS) share common vascular risk factors with atherosclerosis. However, little is known about the relationship between steno-occlusive middle cerebral artery (MCA) and BG-EPVS. In this cross-sectional study, we aimed to test the hypot...

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Autores principales: Du, Houwei, Chen, Chao, Ye, Chengbin, Lin, Feifei, Wei, Jin, Xia, Pincang, Chen, Ronghua, Wu, Sangru, Yuan, Qilin, Chen, Hongbin, Xiao, Yingchun, Liu, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191059/
https://www.ncbi.nlm.nih.gov/pubmed/32390930
http://dx.doi.org/10.3389/fneur.2020.00293
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author Du, Houwei
Chen, Chao
Ye, Chengbin
Lin, Feifei
Wei, Jin
Xia, Pincang
Chen, Ronghua
Wu, Sangru
Yuan, Qilin
Chen, Hongbin
Xiao, Yingchun
Liu, Nan
author_facet Du, Houwei
Chen, Chao
Ye, Chengbin
Lin, Feifei
Wei, Jin
Xia, Pincang
Chen, Ronghua
Wu, Sangru
Yuan, Qilin
Chen, Hongbin
Xiao, Yingchun
Liu, Nan
author_sort Du, Houwei
collection PubMed
description Objectives: Enlarged perivascular spaces in the basal ganglia (BG-EPVS) share common vascular risk factors with atherosclerosis. However, little is known about the relationship between steno-occlusive middle cerebral artery (MCA) and BG-EPVS. In this cross-sectional study, we aimed to test the hypothesis that severe MCA stenosis or occlusion is associated with increased MRI-visible BG-EPVS. Methods: We retrospectively reviewed 112 patients with a steno-occlusive MCA from Fujian Medical University Union Hospital between January 2014 and December 2018. We rated BG-EPVS, white matter hyperintensities (WMH), and lacunes as markers of cerebral small vessel disease (CSVD) on magnetic resonance image (MRI). The severity of steno-occlusive MCA was assessed by computed tomography angiography (CTA) and was classified into moderate (50–69%), severe (70–99%), and occlusion (100%). We evaluated the association of steno-occlusive MCA for >10 BG-EPVS using logistic regression model adjusted for age, gender, hypertension, MR-visible WMH, and lacunes. We also compared the number of BG-EPVS between the affected side and unaffected side in patients with only unilateral steno-occlusive MCA. Results: In multivariable logistic regression analysis, age (OR = 1.07, 95%CI: 1.03–1.13, p = 0.003), hypertension (OR = 2.77, 95%CI: 1.02–7.51, p = 0.046), severe MCA stenosis (OR = 3.65, 95%CI: 1.12–11.87, p = 0.032), or occlusion (OR = 3.67, 95%CI: 1.20–11.27, p = 0.023) were significantly associated with >10 BG-EPVS. The number of BG-EPVS in the affected side was higher than the unaffected side in patients with severe MCA stenosis (12 [9−14] vs. 8 [6−11], p = 0.001) or occlusion (11 [7−14] vs. 8 [5−11], p = 0.028). Conclusions: BG-EPVS were more prevalent in patients with severe MCA atherosclerosis. Our findings suggest a biological link between severe steno-occlusive MCA and increased BG-EPVS. These results need confirmation in prospective studies.
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spelling pubmed-71910592020-05-08 Association Between Steno-Occlusive Middle Cerebral Artery and Basal Ganglia Perivascular Spaces Du, Houwei Chen, Chao Ye, Chengbin Lin, Feifei Wei, Jin Xia, Pincang Chen, Ronghua Wu, Sangru Yuan, Qilin Chen, Hongbin Xiao, Yingchun Liu, Nan Front Neurol Neurology Objectives: Enlarged perivascular spaces in the basal ganglia (BG-EPVS) share common vascular risk factors with atherosclerosis. However, little is known about the relationship between steno-occlusive middle cerebral artery (MCA) and BG-EPVS. In this cross-sectional study, we aimed to test the hypothesis that severe MCA stenosis or occlusion is associated with increased MRI-visible BG-EPVS. Methods: We retrospectively reviewed 112 patients with a steno-occlusive MCA from Fujian Medical University Union Hospital between January 2014 and December 2018. We rated BG-EPVS, white matter hyperintensities (WMH), and lacunes as markers of cerebral small vessel disease (CSVD) on magnetic resonance image (MRI). The severity of steno-occlusive MCA was assessed by computed tomography angiography (CTA) and was classified into moderate (50–69%), severe (70–99%), and occlusion (100%). We evaluated the association of steno-occlusive MCA for >10 BG-EPVS using logistic regression model adjusted for age, gender, hypertension, MR-visible WMH, and lacunes. We also compared the number of BG-EPVS between the affected side and unaffected side in patients with only unilateral steno-occlusive MCA. Results: In multivariable logistic regression analysis, age (OR = 1.07, 95%CI: 1.03–1.13, p = 0.003), hypertension (OR = 2.77, 95%CI: 1.02–7.51, p = 0.046), severe MCA stenosis (OR = 3.65, 95%CI: 1.12–11.87, p = 0.032), or occlusion (OR = 3.67, 95%CI: 1.20–11.27, p = 0.023) were significantly associated with >10 BG-EPVS. The number of BG-EPVS in the affected side was higher than the unaffected side in patients with severe MCA stenosis (12 [9−14] vs. 8 [6−11], p = 0.001) or occlusion (11 [7−14] vs. 8 [5−11], p = 0.028). Conclusions: BG-EPVS were more prevalent in patients with severe MCA atherosclerosis. Our findings suggest a biological link between severe steno-occlusive MCA and increased BG-EPVS. These results need confirmation in prospective studies. Frontiers Media S.A. 2020-04-23 /pmc/articles/PMC7191059/ /pubmed/32390930 http://dx.doi.org/10.3389/fneur.2020.00293 Text en Copyright © 2020 Du, Chen, Ye, Lin, Wei, Xia, Chen, Wu, Yuan, Chen, Xiao and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Du, Houwei
Chen, Chao
Ye, Chengbin
Lin, Feifei
Wei, Jin
Xia, Pincang
Chen, Ronghua
Wu, Sangru
Yuan, Qilin
Chen, Hongbin
Xiao, Yingchun
Liu, Nan
Association Between Steno-Occlusive Middle Cerebral Artery and Basal Ganglia Perivascular Spaces
title Association Between Steno-Occlusive Middle Cerebral Artery and Basal Ganglia Perivascular Spaces
title_full Association Between Steno-Occlusive Middle Cerebral Artery and Basal Ganglia Perivascular Spaces
title_fullStr Association Between Steno-Occlusive Middle Cerebral Artery and Basal Ganglia Perivascular Spaces
title_full_unstemmed Association Between Steno-Occlusive Middle Cerebral Artery and Basal Ganglia Perivascular Spaces
title_short Association Between Steno-Occlusive Middle Cerebral Artery and Basal Ganglia Perivascular Spaces
title_sort association between steno-occlusive middle cerebral artery and basal ganglia perivascular spaces
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191059/
https://www.ncbi.nlm.nih.gov/pubmed/32390930
http://dx.doi.org/10.3389/fneur.2020.00293
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