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Mesoporous Strontium-Doped Phosphate-Based Sol-Gel Glasses for Biomedical Applications
Mesoporous phosphate-based glasses have great potential as biomedical materials being able to simultaneously induce tissue regeneration and controlled release of therapeutic molecules. In the present study, a series of mesoporous phosphate-based glasses in the P(2)O(5)-CaO-Na(2)O system, doped with...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191082/ https://www.ncbi.nlm.nih.gov/pubmed/32391313 http://dx.doi.org/10.3389/fchem.2020.00249 |
Sumario: | Mesoporous phosphate-based glasses have great potential as biomedical materials being able to simultaneously induce tissue regeneration and controlled release of therapeutic molecules. In the present study, a series of mesoporous phosphate-based glasses in the P(2)O(5)-CaO-Na(2)O system, doped with 1, 3, and 5 mol% of Sr(2+), were prepared using the sol-gel method combined with supramolecular templating. A sample without strontium addition was prepared for comparison. The non-ionic triblock copolymer EO(20)PO(70)EO(20) (P123) was used as a templating agent. Scanning electron microscopy (SEM) images revealed that all synthesized glasses have an extended porous structure. This was confirmed by N(2) adsorption-desorption analysis at 77 K that shows a porosity typical of mesoporous materials. (31)P magic angle spinning nuclear magnetic resonance ((31)P MAS-NMR) and Fourier transform infrared (FTIR) spectroscopies have shown that the glasses are mainly formed by Q(1) and Q(2) phosphate groups. Degradation of the glasses in deionized water assessed over a 7-day period shows that phosphate, Ca(2+), Na(+), and Sr(2+) ions can be released in a controlled manner over time. In particular, a direct correlation between strontium content and degradation rate was observed. This study shows that Sr-doped mesoporous phosphate-based glasses have great potential in bone tissue regeneration as materials for controlled delivery of therapeutic ions. |
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