The many faces of the anti-COVID immune response

The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are curre...

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Detalles Bibliográficos
Autores principales: Vardhana, Santosha A., Wolchok, Jedd D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191310/
https://www.ncbi.nlm.nih.gov/pubmed/32353870
http://dx.doi.org/10.1084/jem.20200678
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author Vardhana, Santosha A.
Wolchok, Jedd D.
author_facet Vardhana, Santosha A.
Wolchok, Jedd D.
author_sort Vardhana, Santosha A.
collection PubMed
description The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity.
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spelling pubmed-71913102020-05-04 The many faces of the anti-COVID immune response Vardhana, Santosha A. Wolchok, Jedd D. J Exp Med Perspective The novel 2019 strain of coronavirus is a source of profound morbidity and mortality worldwide. Compared with recent viral outbreaks, COVID-19 infection has a relatively high mortality rate, the reasons for which are not entirely clear. Furthermore, treatment options for COVID-19 infection are currently limited. In this Perspective, we explore the contributions of the innate and adaptive immune systems to both viral control as well as toxicity during COVID-19 infections and offer suggestions to both understand and therapeutically modulate anti-COVID immunity. Rockefeller University Press 2020-04-30 /pmc/articles/PMC7191310/ /pubmed/32353870 http://dx.doi.org/10.1084/jem.20200678 Text en © 2020 Vardhana and Wolchok http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Perspective
Vardhana, Santosha A.
Wolchok, Jedd D.
The many faces of the anti-COVID immune response
title The many faces of the anti-COVID immune response
title_full The many faces of the anti-COVID immune response
title_fullStr The many faces of the anti-COVID immune response
title_full_unstemmed The many faces of the anti-COVID immune response
title_short The many faces of the anti-COVID immune response
title_sort many faces of the anti-covid immune response
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191310/
https://www.ncbi.nlm.nih.gov/pubmed/32353870
http://dx.doi.org/10.1084/jem.20200678
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