Cargando…
Recurrence outcome of lymph node ratio in gastric cancer after underwent curative resection: A retrospective cohort study
INTRODUCTION: D2 dissection has been regarded as the standard procedure for locally advanced gastric cancer (GC). Number of lymph nodes (LN) harvested is an important factor for accurate staging. The number of LN retrieved and the metastasis LN status are also important factors to determine the prog...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191314/ https://www.ncbi.nlm.nih.gov/pubmed/32373343 http://dx.doi.org/10.1016/j.amsu.2020.04.002 |
_version_ | 1783527841881653248 |
---|---|
author | Supsamutchai, Chairat Wilasrusmee, Chumpon Jirasiritham, Jakrapan Rakchob, Teerawut Phosuwan, Songpol Chatmongkonwat, Tanet Choikrua, Pattawia Thampongsa, Tharin |
author_facet | Supsamutchai, Chairat Wilasrusmee, Chumpon Jirasiritham, Jakrapan Rakchob, Teerawut Phosuwan, Songpol Chatmongkonwat, Tanet Choikrua, Pattawia Thampongsa, Tharin |
author_sort | Supsamutchai, Chairat |
collection | PubMed |
description | INTRODUCTION: D2 dissection has been regarded as the standard procedure for locally advanced gastric cancer (GC). Number of lymph nodes (LN) harvested is an important factor for accurate staging. The number of LN retrieved and the metastasis LN status are also important factors to determine the prognosis. This study aims to evaluate whether lymph node ratio (LNR) could be a prognostic indicator of GC patients following curative resection. PATIENTS AND METHODS: Single center retrospective cohort study of GC patients underwent curative resection from January 1995 to December 2016 was conducted. The patients were categorized into 3 groups based on LNR (0.00–0.35, >0.35–0.75, and >0.75–1.00) and 2 groups based on number of LN retrieved (<15 and ≥ 15). Kaplan-Meier method was used to estimate recurrence-free survival. Cox-regression were used to determine the association between LNR/other factors and the disease recurrence. RESULTS: One-hundred fifty-three patients were included in analysis. Univariate analysis showed that LNR >0.35, pathologic LN stages (pN) 2–3, higher number of LN metastasis, and TNM stage III were significantly recurrence risk factors. After adjusting for several covariates, LNR >0.35 still was significant predictor (adjusted HR [95%CI], 8.53 [1.97, 36.86]; p = 0.004) while number of LN retrieved or number of metastasis LN were not. CONCLUSION: LNR could be a strong indicator for the recurrence of GC after curative resection while the number of LN retrieved or metastasis did not predict the recurrence. Future studies, such as prospective studies, are needed to confirm and identify the optimum LNR cut-off. |
format | Online Article Text |
id | pubmed-7191314 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-71913142020-05-05 Recurrence outcome of lymph node ratio in gastric cancer after underwent curative resection: A retrospective cohort study Supsamutchai, Chairat Wilasrusmee, Chumpon Jirasiritham, Jakrapan Rakchob, Teerawut Phosuwan, Songpol Chatmongkonwat, Tanet Choikrua, Pattawia Thampongsa, Tharin Ann Med Surg (Lond) Original Research INTRODUCTION: D2 dissection has been regarded as the standard procedure for locally advanced gastric cancer (GC). Number of lymph nodes (LN) harvested is an important factor for accurate staging. The number of LN retrieved and the metastasis LN status are also important factors to determine the prognosis. This study aims to evaluate whether lymph node ratio (LNR) could be a prognostic indicator of GC patients following curative resection. PATIENTS AND METHODS: Single center retrospective cohort study of GC patients underwent curative resection from January 1995 to December 2016 was conducted. The patients were categorized into 3 groups based on LNR (0.00–0.35, >0.35–0.75, and >0.75–1.00) and 2 groups based on number of LN retrieved (<15 and ≥ 15). Kaplan-Meier method was used to estimate recurrence-free survival. Cox-regression were used to determine the association between LNR/other factors and the disease recurrence. RESULTS: One-hundred fifty-three patients were included in analysis. Univariate analysis showed that LNR >0.35, pathologic LN stages (pN) 2–3, higher number of LN metastasis, and TNM stage III were significantly recurrence risk factors. After adjusting for several covariates, LNR >0.35 still was significant predictor (adjusted HR [95%CI], 8.53 [1.97, 36.86]; p = 0.004) while number of LN retrieved or number of metastasis LN were not. CONCLUSION: LNR could be a strong indicator for the recurrence of GC after curative resection while the number of LN retrieved or metastasis did not predict the recurrence. Future studies, such as prospective studies, are needed to confirm and identify the optimum LNR cut-off. Elsevier 2020-04-19 /pmc/articles/PMC7191314/ /pubmed/32373343 http://dx.doi.org/10.1016/j.amsu.2020.04.002 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Research Supsamutchai, Chairat Wilasrusmee, Chumpon Jirasiritham, Jakrapan Rakchob, Teerawut Phosuwan, Songpol Chatmongkonwat, Tanet Choikrua, Pattawia Thampongsa, Tharin Recurrence outcome of lymph node ratio in gastric cancer after underwent curative resection: A retrospective cohort study |
title | Recurrence outcome of lymph node ratio in gastric cancer after underwent curative resection: A retrospective cohort study |
title_full | Recurrence outcome of lymph node ratio in gastric cancer after underwent curative resection: A retrospective cohort study |
title_fullStr | Recurrence outcome of lymph node ratio in gastric cancer after underwent curative resection: A retrospective cohort study |
title_full_unstemmed | Recurrence outcome of lymph node ratio in gastric cancer after underwent curative resection: A retrospective cohort study |
title_short | Recurrence outcome of lymph node ratio in gastric cancer after underwent curative resection: A retrospective cohort study |
title_sort | recurrence outcome of lymph node ratio in gastric cancer after underwent curative resection: a retrospective cohort study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191314/ https://www.ncbi.nlm.nih.gov/pubmed/32373343 http://dx.doi.org/10.1016/j.amsu.2020.04.002 |
work_keys_str_mv | AT supsamutchaichairat recurrenceoutcomeoflymphnoderatioingastriccancerafterunderwentcurativeresectionaretrospectivecohortstudy AT wilasrusmeechumpon recurrenceoutcomeoflymphnoderatioingastriccancerafterunderwentcurativeresectionaretrospectivecohortstudy AT jirasirithamjakrapan recurrenceoutcomeoflymphnoderatioingastriccancerafterunderwentcurativeresectionaretrospectivecohortstudy AT rakchobteerawut recurrenceoutcomeoflymphnoderatioingastriccancerafterunderwentcurativeresectionaretrospectivecohortstudy AT phosuwansongpol recurrenceoutcomeoflymphnoderatioingastriccancerafterunderwentcurativeresectionaretrospectivecohortstudy AT chatmongkonwattanet recurrenceoutcomeoflymphnoderatioingastriccancerafterunderwentcurativeresectionaretrospectivecohortstudy AT choikruapattawia recurrenceoutcomeoflymphnoderatioingastriccancerafterunderwentcurativeresectionaretrospectivecohortstudy AT thampongsatharin recurrenceoutcomeoflymphnoderatioingastriccancerafterunderwentcurativeresectionaretrospectivecohortstudy |