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Bismuth Porphyrin Antagonizes Cisplatin-Induced Nephrotoxicity via Unexpected Metallothionein-Independent Mechanisms

Cisplatin (CDDP) has been a highly successful anticancer drug in cancer therapy; however, its further application suffers severe nephrotoxicity. Herein, we identify bismuth tetraphenylporphyrinate [Bi(TPP)] as a potent protective agent against CDDP-induced nephrotoxicity. Bi(TPP) attenuates CDDP-ind...

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Detalles Bibliográficos
Autores principales:	Wang, Runming, Wang, Suyu, Chan, Shing, Wang, Yuchuan, Zhang, Yufeng, Zuo, Zhong, Chi-Fung Chan, Godfrey, Li, Hongyan, Sun, Hongzhe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191608/ https://www.ncbi.nlm.nih.gov/pubmed/32353763 http://dx.doi.org/10.1016/j.isci.2020.101054

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