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Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis
BACKGROUND: Inflammatory stimuli induce immunoresponsive gene 1 (IRG1) expression that in turn catalyzes the production of itaconate from the tricarboxylic acid cycle. Itaconate has recently emerged as a regulator of immune cell functions, especially in macrophages. Studies show that itaconate is re...
Autores principales: | Kuo, Ping-Chang, Weng, Wen-Tsan, Scofield, Barbara A., Paraiso, Hallel C., Brown, Dennis A., Wang, Pei-Yu, Yu, I-Chen, Yen, Jui-Hung |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191722/ https://www.ncbi.nlm.nih.gov/pubmed/32349768 http://dx.doi.org/10.1186/s12974-020-01768-7 |
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