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Regenerative and protective effects of dMSC-sEVs on high-glucose-induced senescent fibroblasts by suppressing RAGE pathway and activating Smad pathway

BACKGROUND: Fibroblasts are crucial for supporting normal wound healing. However, the functional state of these cells is impaired in diabetics because of a high-glucose (HG) microenvironment. Small extracellular vesicles (sEVs) have emerged as a promising tool for skin wound treatment. The aim of th...

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Detalles Bibliográficos
Autores principales:	Bian, Xiaowei, Li, Bingmin, Yang, Jie, Ma, Kui, Sun, Mengli, Zhang, Cuiping, Fu, Xiaobing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191792/ https://www.ncbi.nlm.nih.gov/pubmed/32349787 http://dx.doi.org/10.1186/s13287-020-01681-z

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