Development and Scale-up of the Rapid Synthesis of Triphenyl Phosphites in Continuous Flow

[Image: see text] A novel method for the synthesis of triphenyl phosphite and its derivatives has been developed in continuous flow. With a total residence time of 20 s, the target product was prepared in a microreactor, and the reaction time was significantly shortened compared with standard single...

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Autores principales: Mao, Mengmei, Zhang, Le, Yao, Hanlin, Wan, Li, Xin, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191834/
https://www.ncbi.nlm.nih.gov/pubmed/32363302
http://dx.doi.org/10.1021/acsomega.0c00716
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author Mao, Mengmei
Zhang, Le
Yao, Hanlin
Wan, Li
Xin, Zhong
author_facet Mao, Mengmei
Zhang, Le
Yao, Hanlin
Wan, Li
Xin, Zhong
author_sort Mao, Mengmei
collection PubMed
description [Image: see text] A novel method for the synthesis of triphenyl phosphite and its derivatives has been developed in continuous flow. With a total residence time of 20 s, the target product was prepared in a microreactor, and the reaction time was significantly shortened compared with standard single batch reaction conditions. In addition, the reaction of various substrates gave the corresponding products in good to excellent yields under optimized conditions. The reactants could be employed in a stoichiometric ratio, making the reaction more efficient, economical, and environmentally friendly. In addition, scale-up apparatus was designed and assembled, and the kilogram-scale production (up to 18.4 kg/h) of tris(2,4-di-tert-butylphenyl) phosphite was achieved in 88% yield.
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spelling pubmed-71918342020-05-01 Development and Scale-up of the Rapid Synthesis of Triphenyl Phosphites in Continuous Flow Mao, Mengmei Zhang, Le Yao, Hanlin Wan, Li Xin, Zhong ACS Omega [Image: see text] A novel method for the synthesis of triphenyl phosphite and its derivatives has been developed in continuous flow. With a total residence time of 20 s, the target product was prepared in a microreactor, and the reaction time was significantly shortened compared with standard single batch reaction conditions. In addition, the reaction of various substrates gave the corresponding products in good to excellent yields under optimized conditions. The reactants could be employed in a stoichiometric ratio, making the reaction more efficient, economical, and environmentally friendly. In addition, scale-up apparatus was designed and assembled, and the kilogram-scale production (up to 18.4 kg/h) of tris(2,4-di-tert-butylphenyl) phosphite was achieved in 88% yield. American Chemical Society 2020-04-17 /pmc/articles/PMC7191834/ /pubmed/32363302 http://dx.doi.org/10.1021/acsomega.0c00716 Text en Copyright © 2020 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle Mao, Mengmei
Zhang, Le
Yao, Hanlin
Wan, Li
Xin, Zhong
Development and Scale-up of the Rapid Synthesis of Triphenyl Phosphites in Continuous Flow
title Development and Scale-up of the Rapid Synthesis of Triphenyl Phosphites in Continuous Flow
title_full Development and Scale-up of the Rapid Synthesis of Triphenyl Phosphites in Continuous Flow
title_fullStr Development and Scale-up of the Rapid Synthesis of Triphenyl Phosphites in Continuous Flow
title_full_unstemmed Development and Scale-up of the Rapid Synthesis of Triphenyl Phosphites in Continuous Flow
title_short Development and Scale-up of the Rapid Synthesis of Triphenyl Phosphites in Continuous Flow
title_sort development and scale-up of the rapid synthesis of triphenyl phosphites in continuous flow
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191834/
https://www.ncbi.nlm.nih.gov/pubmed/32363302
http://dx.doi.org/10.1021/acsomega.0c00716
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