Synthesis and biological evaluation of new 3(2H)-pyridazinone derivatives as non-toxic anti-proliferative compounds against human colon carcinoma HCT116 cells

Novel 3(2H)-pyridazinone derivatives were designed, synthesised in satisfactory yields and evaluated in different experimental assays to assess their preliminary toxicity in vivo and anti-proliferative effects against HCT116 cell lines in vitro. Artemia salina lethality test provided LC(50) values &...

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Detalles Bibliográficos
Autores principales: Özdemir, Zeynep, Utku, Semra, Mathew, Bijo, Carradori, Simone, Orlando, Giustino, Di Simone, Simonetta, Alagöz, Mehmet Abdullah, Özçelik, Azime Berna, Uysal, Mehtap, Ferrante, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191905/
https://www.ncbi.nlm.nih.gov/pubmed/32321320
http://dx.doi.org/10.1080/14756366.2020.1755670

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