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Inducing Partner Preference in Mice by Chemogenetic Stimulation of CA2 Hippocampal Subfield
Social recognition is fundamental for social decision making and the establishment of long-lasting affiliative behaviors in behaviorally complex social groups. It is a critical step in establishing a selective preference for a social partner or group member. C57BL/6J lab mice do not form monogamous...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192236/ https://www.ncbi.nlm.nih.gov/pubmed/32390799 http://dx.doi.org/10.3389/fnmol.2020.00061 |
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author | Cymerblit-Sabba, Adi Smith, Adam S. Williams Avram, Sarah K. Stackmann, Michelle Korgan, Austin C. Tickerhoof, Maria C. Young, W. Scott |
author_facet | Cymerblit-Sabba, Adi Smith, Adam S. Williams Avram, Sarah K. Stackmann, Michelle Korgan, Austin C. Tickerhoof, Maria C. Young, W. Scott |
author_sort | Cymerblit-Sabba, Adi |
collection | PubMed |
description | Social recognition is fundamental for social decision making and the establishment of long-lasting affiliative behaviors in behaviorally complex social groups. It is a critical step in establishing a selective preference for a social partner or group member. C57BL/6J lab mice do not form monogamous relationships, and typically do not show prolonged social preferences for familiar mice. The CA2 hippocampal subfield plays a crucial role in social memory and optogenetic stimulation of inputs to the dorsal CA2 field during a short memory acquisition period can enhance and extend social memories in mice. Here, we show that partner preference in mice can be induced by chemogenetic selective stimulation of the monosynaptic projections from the hypothalamic paraventricular nucleus (PVN) to the CA2 during the cohabitation period. Specifically, male mice spend more time in social contact, grooming and huddling with the partner compared to a novel female. Preference was not induced by prolonging the cohabitation period and allowing more time for social interactions and males to sire pups with the familiar female. These results suggest that PVN-to-CA2 projections are part of an evolutionarily conserved neural circuitry underlying the formation of social preference and may promote behavioral changes with appropriate stimulation. |
format | Online Article Text |
id | pubmed-7192236 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71922362020-05-08 Inducing Partner Preference in Mice by Chemogenetic Stimulation of CA2 Hippocampal Subfield Cymerblit-Sabba, Adi Smith, Adam S. Williams Avram, Sarah K. Stackmann, Michelle Korgan, Austin C. Tickerhoof, Maria C. Young, W. Scott Front Mol Neurosci Neuroscience Social recognition is fundamental for social decision making and the establishment of long-lasting affiliative behaviors in behaviorally complex social groups. It is a critical step in establishing a selective preference for a social partner or group member. C57BL/6J lab mice do not form monogamous relationships, and typically do not show prolonged social preferences for familiar mice. The CA2 hippocampal subfield plays a crucial role in social memory and optogenetic stimulation of inputs to the dorsal CA2 field during a short memory acquisition period can enhance and extend social memories in mice. Here, we show that partner preference in mice can be induced by chemogenetic selective stimulation of the monosynaptic projections from the hypothalamic paraventricular nucleus (PVN) to the CA2 during the cohabitation period. Specifically, male mice spend more time in social contact, grooming and huddling with the partner compared to a novel female. Preference was not induced by prolonging the cohabitation period and allowing more time for social interactions and males to sire pups with the familiar female. These results suggest that PVN-to-CA2 projections are part of an evolutionarily conserved neural circuitry underlying the formation of social preference and may promote behavioral changes with appropriate stimulation. Frontiers Media S.A. 2020-04-23 /pmc/articles/PMC7192236/ /pubmed/32390799 http://dx.doi.org/10.3389/fnmol.2020.00061 Text en Copyright © 2020 Cymerblit-Sabba, Smith, Williams Avram, Stackmann, Korgan, Tickerhoof and Young. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Cymerblit-Sabba, Adi Smith, Adam S. Williams Avram, Sarah K. Stackmann, Michelle Korgan, Austin C. Tickerhoof, Maria C. Young, W. Scott Inducing Partner Preference in Mice by Chemogenetic Stimulation of CA2 Hippocampal Subfield |
title | Inducing Partner Preference in Mice by Chemogenetic Stimulation of CA2 Hippocampal Subfield |
title_full | Inducing Partner Preference in Mice by Chemogenetic Stimulation of CA2 Hippocampal Subfield |
title_fullStr | Inducing Partner Preference in Mice by Chemogenetic Stimulation of CA2 Hippocampal Subfield |
title_full_unstemmed | Inducing Partner Preference in Mice by Chemogenetic Stimulation of CA2 Hippocampal Subfield |
title_short | Inducing Partner Preference in Mice by Chemogenetic Stimulation of CA2 Hippocampal Subfield |
title_sort | inducing partner preference in mice by chemogenetic stimulation of ca2 hippocampal subfield |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192236/ https://www.ncbi.nlm.nih.gov/pubmed/32390799 http://dx.doi.org/10.3389/fnmol.2020.00061 |
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