Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment

The precise relationship between epigenetic alterations and telomere dysfunction is still an extant question. Previously, we showed that eroded telomeres lead to differentiation instability in murine embryonic stem cells (mESCs) via DNA hypomethylation at pluripotency-factor promoters. Here, we unco...

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Detalles Bibliográficos
Autores principales: Criqui, Mélanie, Qamra, Aditi, Chu, Tsz Wai, Sharma, Monika, Tsao, Julissa, Henry, Danielle A, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H, Winegarden, Neil, Lupien, Mathieu, Harrington, Lea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192583/
https://www.ncbi.nlm.nih.gov/pubmed/32297856
http://dx.doi.org/10.7554/eLife.47333

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