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Direct observation and analysis of TET-mediated oxidation processes in a DNA origami nanochip

DNA methylation and demethylation play a key role in the epigenetic regulation of gene expression; however, a series of oxidation reactions of 5-methyl cytosine (5mC) mediated by ten-eleven translocation (TET) enzymes driving demethylation process are yet to be uncovered. To elucidate the relationsh...

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Detalles Bibliográficos
Autores principales:	Xing, Xiwen, Sato, Shinsuke, Wong, Nai-Kei, Hidaka, Kumi, Sugiyama, Hiroshi, Endo, Masayuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192588/ https://www.ncbi.nlm.nih.gov/pubmed/32170318 http://dx.doi.org/10.1093/nar/gkaa137

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