Epigenetic engineering of yeast reveals dynamic molecular adaptation to methylation stress and genetic modulators of specific DNMT3 family members

Cytosine methylation is a ubiquitous modification in mammalian DNA generated and maintained by several DNA methyltransferases (DNMTs) with partially overlapping functions and genomic targets. To systematically dissect the factors specifying each DNMT’s activity, we engineered combinatorial knock-in...

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Detalles Bibliográficos
Autores principales: Finnegan, Alex I, Kim, Somang, Jin, Hu, Gapinske, Michael, Woods, Wendy S, Perez-Pinera, Pablo, Song, Jun S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192628/
https://www.ncbi.nlm.nih.gov/pubmed/32187373
http://dx.doi.org/10.1093/nar/gkaa161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192628/
https://www.ncbi.nlm.nih.gov/pubmed/32187373
http://dx.doi.org/10.1093/nar/gkaa161

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