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The Incidence and Associated Factors of Sudden Death in Patients on Hemodialysis: 10-Year Outcome of the Q-Cohort Study

Aim: The incidence of sudden death and its risk factors in patients on hemodialysis remain unclear. This study aimed to clarify the incidence of sudden death and its risk factors in Japanese patients on hemodialysis. Methods: A total of 3505 patients on hemodialysis aged ≥ 18 years were followed for...

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Autores principales: Hiyamuta, Hiroto, Tanaka, Shigeru, Taniguchi, Masatomo, Tokumoto, Masanori, Fujisaki, Kiichiro, Nakano, Toshiaki, Tsuruya, Kazuhiko, Kitazono, Takanari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Atherosclerosis Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192813/
https://www.ncbi.nlm.nih.gov/pubmed/31434843
http://dx.doi.org/10.5551/jat.49833
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author Hiyamuta, Hiroto
Tanaka, Shigeru
Taniguchi, Masatomo
Tokumoto, Masanori
Fujisaki, Kiichiro
Nakano, Toshiaki
Tsuruya, Kazuhiko
Kitazono, Takanari
author_facet Hiyamuta, Hiroto
Tanaka, Shigeru
Taniguchi, Masatomo
Tokumoto, Masanori
Fujisaki, Kiichiro
Nakano, Toshiaki
Tsuruya, Kazuhiko
Kitazono, Takanari
author_sort Hiyamuta, Hiroto
collection PubMed
description Aim: The incidence of sudden death and its risk factors in patients on hemodialysis remain unclear. This study aimed to clarify the incidence of sudden death and its risk factors in Japanese patients on hemodialysis. Methods: A total of 3505 patients on hemodialysis aged ≥ 18 years were followed for 10 years. Multivariate-adjusted hazard ratio (HR) with 95% confidence interval (95% CI) of each risk factor of sudden death were calculated using a Cox proportional hazards model. Results: During the 10-year follow-up, 1735 patients died, including 227 (13%) sudden deaths. The incidence rate of sudden death was 9.13 per 1000 person-years. In multivariable-adjusted Cox analysis, male sex (HR 1.67; 95% CI 1.20–2.33), age (HR 1.44; 95% CI 1.26–1.65 per 10-year higher), the presence of diabetes (HR 2.45; 95% CI 1.82–3.29), history of cardiovascular disease (HR 1.85; 95% CI 1.38–2.46), cardiothoracic ratio (HR 1.21; 95% CI 1.07–1.39 per 5% higher), serum C-reactive protein (HR 1.11; 95% CI 1.03–1.20 per 1-mg/dL higher), and serum phosphate (HR 1.15; 95% CI 1.03–1.30 per 1-mg/dL higher) were independent predictors of sudden death. A subgroup analysis stratified by sex or age showed that lower serum corrected calcium levels, not using vitamin D receptor activators in women, and a shorter dialysis session length in men or older people (≥ 65 years) increased the risk for sudden death. Conclusions: This study clarified the incidence of sudden death and its specific predictors in Japanese patients on hemodialysis.
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spelling pubmed-71928132020-05-06 The Incidence and Associated Factors of Sudden Death in Patients on Hemodialysis: 10-Year Outcome of the Q-Cohort Study Hiyamuta, Hiroto Tanaka, Shigeru Taniguchi, Masatomo Tokumoto, Masanori Fujisaki, Kiichiro Nakano, Toshiaki Tsuruya, Kazuhiko Kitazono, Takanari J Atheroscler Thromb Original Article Aim: The incidence of sudden death and its risk factors in patients on hemodialysis remain unclear. This study aimed to clarify the incidence of sudden death and its risk factors in Japanese patients on hemodialysis. Methods: A total of 3505 patients on hemodialysis aged ≥ 18 years were followed for 10 years. Multivariate-adjusted hazard ratio (HR) with 95% confidence interval (95% CI) of each risk factor of sudden death were calculated using a Cox proportional hazards model. Results: During the 10-year follow-up, 1735 patients died, including 227 (13%) sudden deaths. The incidence rate of sudden death was 9.13 per 1000 person-years. In multivariable-adjusted Cox analysis, male sex (HR 1.67; 95% CI 1.20–2.33), age (HR 1.44; 95% CI 1.26–1.65 per 10-year higher), the presence of diabetes (HR 2.45; 95% CI 1.82–3.29), history of cardiovascular disease (HR 1.85; 95% CI 1.38–2.46), cardiothoracic ratio (HR 1.21; 95% CI 1.07–1.39 per 5% higher), serum C-reactive protein (HR 1.11; 95% CI 1.03–1.20 per 1-mg/dL higher), and serum phosphate (HR 1.15; 95% CI 1.03–1.30 per 1-mg/dL higher) were independent predictors of sudden death. A subgroup analysis stratified by sex or age showed that lower serum corrected calcium levels, not using vitamin D receptor activators in women, and a shorter dialysis session length in men or older people (≥ 65 years) increased the risk for sudden death. Conclusions: This study clarified the incidence of sudden death and its specific predictors in Japanese patients on hemodialysis. Japan Atherosclerosis Society 2020-04-01 /pmc/articles/PMC7192813/ /pubmed/31434843 http://dx.doi.org/10.5551/jat.49833 Text en 2020 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Original Article
Hiyamuta, Hiroto
Tanaka, Shigeru
Taniguchi, Masatomo
Tokumoto, Masanori
Fujisaki, Kiichiro
Nakano, Toshiaki
Tsuruya, Kazuhiko
Kitazono, Takanari
The Incidence and Associated Factors of Sudden Death in Patients on Hemodialysis: 10-Year Outcome of the Q-Cohort Study
title The Incidence and Associated Factors of Sudden Death in Patients on Hemodialysis: 10-Year Outcome of the Q-Cohort Study
title_full The Incidence and Associated Factors of Sudden Death in Patients on Hemodialysis: 10-Year Outcome of the Q-Cohort Study
title_fullStr The Incidence and Associated Factors of Sudden Death in Patients on Hemodialysis: 10-Year Outcome of the Q-Cohort Study
title_full_unstemmed The Incidence and Associated Factors of Sudden Death in Patients on Hemodialysis: 10-Year Outcome of the Q-Cohort Study
title_short The Incidence and Associated Factors of Sudden Death in Patients on Hemodialysis: 10-Year Outcome of the Q-Cohort Study
title_sort incidence and associated factors of sudden death in patients on hemodialysis: 10-year outcome of the q-cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192813/
https://www.ncbi.nlm.nih.gov/pubmed/31434843
http://dx.doi.org/10.5551/jat.49833
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