Cargando…
The Incidence and Associated Factors of Sudden Death in Patients on Hemodialysis: 10-Year Outcome of the Q-Cohort Study
Aim: The incidence of sudden death and its risk factors in patients on hemodialysis remain unclear. This study aimed to clarify the incidence of sudden death and its risk factors in Japanese patients on hemodialysis. Methods: A total of 3505 patients on hemodialysis aged ≥ 18 years were followed for...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japan Atherosclerosis Society
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192813/ https://www.ncbi.nlm.nih.gov/pubmed/31434843 http://dx.doi.org/10.5551/jat.49833 |
_version_ | 1783528071238778880 |
---|---|
author | Hiyamuta, Hiroto Tanaka, Shigeru Taniguchi, Masatomo Tokumoto, Masanori Fujisaki, Kiichiro Nakano, Toshiaki Tsuruya, Kazuhiko Kitazono, Takanari |
author_facet | Hiyamuta, Hiroto Tanaka, Shigeru Taniguchi, Masatomo Tokumoto, Masanori Fujisaki, Kiichiro Nakano, Toshiaki Tsuruya, Kazuhiko Kitazono, Takanari |
author_sort | Hiyamuta, Hiroto |
collection | PubMed |
description | Aim: The incidence of sudden death and its risk factors in patients on hemodialysis remain unclear. This study aimed to clarify the incidence of sudden death and its risk factors in Japanese patients on hemodialysis. Methods: A total of 3505 patients on hemodialysis aged ≥ 18 years were followed for 10 years. Multivariate-adjusted hazard ratio (HR) with 95% confidence interval (95% CI) of each risk factor of sudden death were calculated using a Cox proportional hazards model. Results: During the 10-year follow-up, 1735 patients died, including 227 (13%) sudden deaths. The incidence rate of sudden death was 9.13 per 1000 person-years. In multivariable-adjusted Cox analysis, male sex (HR 1.67; 95% CI 1.20–2.33), age (HR 1.44; 95% CI 1.26–1.65 per 10-year higher), the presence of diabetes (HR 2.45; 95% CI 1.82–3.29), history of cardiovascular disease (HR 1.85; 95% CI 1.38–2.46), cardiothoracic ratio (HR 1.21; 95% CI 1.07–1.39 per 5% higher), serum C-reactive protein (HR 1.11; 95% CI 1.03–1.20 per 1-mg/dL higher), and serum phosphate (HR 1.15; 95% CI 1.03–1.30 per 1-mg/dL higher) were independent predictors of sudden death. A subgroup analysis stratified by sex or age showed that lower serum corrected calcium levels, not using vitamin D receptor activators in women, and a shorter dialysis session length in men or older people (≥ 65 years) increased the risk for sudden death. Conclusions: This study clarified the incidence of sudden death and its specific predictors in Japanese patients on hemodialysis. |
format | Online Article Text |
id | pubmed-7192813 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Japan Atherosclerosis Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-71928132020-05-06 The Incidence and Associated Factors of Sudden Death in Patients on Hemodialysis: 10-Year Outcome of the Q-Cohort Study Hiyamuta, Hiroto Tanaka, Shigeru Taniguchi, Masatomo Tokumoto, Masanori Fujisaki, Kiichiro Nakano, Toshiaki Tsuruya, Kazuhiko Kitazono, Takanari J Atheroscler Thromb Original Article Aim: The incidence of sudden death and its risk factors in patients on hemodialysis remain unclear. This study aimed to clarify the incidence of sudden death and its risk factors in Japanese patients on hemodialysis. Methods: A total of 3505 patients on hemodialysis aged ≥ 18 years were followed for 10 years. Multivariate-adjusted hazard ratio (HR) with 95% confidence interval (95% CI) of each risk factor of sudden death were calculated using a Cox proportional hazards model. Results: During the 10-year follow-up, 1735 patients died, including 227 (13%) sudden deaths. The incidence rate of sudden death was 9.13 per 1000 person-years. In multivariable-adjusted Cox analysis, male sex (HR 1.67; 95% CI 1.20–2.33), age (HR 1.44; 95% CI 1.26–1.65 per 10-year higher), the presence of diabetes (HR 2.45; 95% CI 1.82–3.29), history of cardiovascular disease (HR 1.85; 95% CI 1.38–2.46), cardiothoracic ratio (HR 1.21; 95% CI 1.07–1.39 per 5% higher), serum C-reactive protein (HR 1.11; 95% CI 1.03–1.20 per 1-mg/dL higher), and serum phosphate (HR 1.15; 95% CI 1.03–1.30 per 1-mg/dL higher) were independent predictors of sudden death. A subgroup analysis stratified by sex or age showed that lower serum corrected calcium levels, not using vitamin D receptor activators in women, and a shorter dialysis session length in men or older people (≥ 65 years) increased the risk for sudden death. Conclusions: This study clarified the incidence of sudden death and its specific predictors in Japanese patients on hemodialysis. Japan Atherosclerosis Society 2020-04-01 /pmc/articles/PMC7192813/ /pubmed/31434843 http://dx.doi.org/10.5551/jat.49833 Text en 2020 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Original Article Hiyamuta, Hiroto Tanaka, Shigeru Taniguchi, Masatomo Tokumoto, Masanori Fujisaki, Kiichiro Nakano, Toshiaki Tsuruya, Kazuhiko Kitazono, Takanari The Incidence and Associated Factors of Sudden Death in Patients on Hemodialysis: 10-Year Outcome of the Q-Cohort Study |
title | The Incidence and Associated Factors of Sudden Death in Patients on Hemodialysis: 10-Year Outcome of the Q-Cohort Study |
title_full | The Incidence and Associated Factors of Sudden Death in Patients on Hemodialysis: 10-Year Outcome of the Q-Cohort Study |
title_fullStr | The Incidence and Associated Factors of Sudden Death in Patients on Hemodialysis: 10-Year Outcome of the Q-Cohort Study |
title_full_unstemmed | The Incidence and Associated Factors of Sudden Death in Patients on Hemodialysis: 10-Year Outcome of the Q-Cohort Study |
title_short | The Incidence and Associated Factors of Sudden Death in Patients on Hemodialysis: 10-Year Outcome of the Q-Cohort Study |
title_sort | incidence and associated factors of sudden death in patients on hemodialysis: 10-year outcome of the q-cohort study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192813/ https://www.ncbi.nlm.nih.gov/pubmed/31434843 http://dx.doi.org/10.5551/jat.49833 |
work_keys_str_mv | AT hiyamutahiroto theincidenceandassociatedfactorsofsuddendeathinpatientsonhemodialysis10yearoutcomeoftheqcohortstudy AT tanakashigeru theincidenceandassociatedfactorsofsuddendeathinpatientsonhemodialysis10yearoutcomeoftheqcohortstudy AT taniguchimasatomo theincidenceandassociatedfactorsofsuddendeathinpatientsonhemodialysis10yearoutcomeoftheqcohortstudy AT tokumotomasanori theincidenceandassociatedfactorsofsuddendeathinpatientsonhemodialysis10yearoutcomeoftheqcohortstudy AT fujisakikiichiro theincidenceandassociatedfactorsofsuddendeathinpatientsonhemodialysis10yearoutcomeoftheqcohortstudy AT nakanotoshiaki theincidenceandassociatedfactorsofsuddendeathinpatientsonhemodialysis10yearoutcomeoftheqcohortstudy AT tsuruyakazuhiko theincidenceandassociatedfactorsofsuddendeathinpatientsonhemodialysis10yearoutcomeoftheqcohortstudy AT kitazonotakanari theincidenceandassociatedfactorsofsuddendeathinpatientsonhemodialysis10yearoutcomeoftheqcohortstudy AT hiyamutahiroto incidenceandassociatedfactorsofsuddendeathinpatientsonhemodialysis10yearoutcomeoftheqcohortstudy AT tanakashigeru incidenceandassociatedfactorsofsuddendeathinpatientsonhemodialysis10yearoutcomeoftheqcohortstudy AT taniguchimasatomo incidenceandassociatedfactorsofsuddendeathinpatientsonhemodialysis10yearoutcomeoftheqcohortstudy AT tokumotomasanori incidenceandassociatedfactorsofsuddendeathinpatientsonhemodialysis10yearoutcomeoftheqcohortstudy AT fujisakikiichiro incidenceandassociatedfactorsofsuddendeathinpatientsonhemodialysis10yearoutcomeoftheqcohortstudy AT nakanotoshiaki incidenceandassociatedfactorsofsuddendeathinpatientsonhemodialysis10yearoutcomeoftheqcohortstudy AT tsuruyakazuhiko incidenceandassociatedfactorsofsuddendeathinpatientsonhemodialysis10yearoutcomeoftheqcohortstudy AT kitazonotakanari incidenceandassociatedfactorsofsuddendeathinpatientsonhemodialysis10yearoutcomeoftheqcohortstudy |