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Relationships of Obesity-Related Indices and Metabolic Syndrome with Subclinical Atherosclerosis in Middle-Aged Untreated Japanese Workers

Aim: Obesity is a social problem due to the prevalence of the Western lifestyle. In particular, visceral fat accumulation, which is a main component of metabolic syndrome, is closely associated with the progression of atherosclerosis. This study aimed to investigate the relationships of obesity-rela...

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Autores principales: Sugiura, Tomonori, Dohi, Yasuaki, Takagi, Yasuyuki, Yoshikane, Naofumi, Ito, Mitsuhisa, Suzuki, Kenji, Nagami, Takashi, Iwase, Mitsunori, Seo, Yoshihiro, Ohte, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Atherosclerosis Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192820/
https://www.ncbi.nlm.nih.gov/pubmed/31462618
http://dx.doi.org/10.5551/jat.50633
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author Sugiura, Tomonori
Dohi, Yasuaki
Takagi, Yasuyuki
Yoshikane, Naofumi
Ito, Mitsuhisa
Suzuki, Kenji
Nagami, Takashi
Iwase, Mitsunori
Seo, Yoshihiro
Ohte, Nobuyuki
author_facet Sugiura, Tomonori
Dohi, Yasuaki
Takagi, Yasuyuki
Yoshikane, Naofumi
Ito, Mitsuhisa
Suzuki, Kenji
Nagami, Takashi
Iwase, Mitsunori
Seo, Yoshihiro
Ohte, Nobuyuki
author_sort Sugiura, Tomonori
collection PubMed
description Aim: Obesity is a social problem due to the prevalence of the Western lifestyle. In particular, visceral fat accumulation, which is a main component of metabolic syndrome, is closely associated with the progression of atherosclerosis. This study aimed to investigate the relationships of obesity-related indices and metabolic syndrome with subclinical atherosclerosis in middle-aged untreated workers. Methods: Employees undergoing their periodic health check-up but without previous cardiovascular events or cardiovascular medications were enrolled in this study (n = 7,750). Body mass index (BMI), percent body fat, waist circumference, and visceral fat area were evaluated as obesity-related indices. Assessment of visceral fat area was performed by computed tomography (CT). Subclinical atherosclerosis was assessed by measuring arterial stiffness using cardio-ankle vascular index (CAVI) and by ultrasound examination of carotid intima-media thickness (IMT). Results: Obesity-related indices were significantly correlated with each other and were positively associated with carotid IMT but negatively associated with CAVI in multivariate regression analysis. In a logistic regression analysis including CAVI and carotid IMT simultaneously, CAVI was negatively associated, but carotid IMT was positively associated, with obesity defined by each obesity-related index. In contrast, both CAVI and carotid IMT were positively associated with the presence of metabolic syndrome based on visceral fat accumulation. Conclusions: Obesity-related indices were negatively associated with CAVI and positively associated with carotid IMT in middle-aged untreated workers, while both CAVI and carotid IMT were worsened in the presence of metabolic syndrome.
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spelling pubmed-71928202020-05-06 Relationships of Obesity-Related Indices and Metabolic Syndrome with Subclinical Atherosclerosis in Middle-Aged Untreated Japanese Workers Sugiura, Tomonori Dohi, Yasuaki Takagi, Yasuyuki Yoshikane, Naofumi Ito, Mitsuhisa Suzuki, Kenji Nagami, Takashi Iwase, Mitsunori Seo, Yoshihiro Ohte, Nobuyuki J Atheroscler Thromb Original Article Aim: Obesity is a social problem due to the prevalence of the Western lifestyle. In particular, visceral fat accumulation, which is a main component of metabolic syndrome, is closely associated with the progression of atherosclerosis. This study aimed to investigate the relationships of obesity-related indices and metabolic syndrome with subclinical atherosclerosis in middle-aged untreated workers. Methods: Employees undergoing their periodic health check-up but without previous cardiovascular events or cardiovascular medications were enrolled in this study (n = 7,750). Body mass index (BMI), percent body fat, waist circumference, and visceral fat area were evaluated as obesity-related indices. Assessment of visceral fat area was performed by computed tomography (CT). Subclinical atherosclerosis was assessed by measuring arterial stiffness using cardio-ankle vascular index (CAVI) and by ultrasound examination of carotid intima-media thickness (IMT). Results: Obesity-related indices were significantly correlated with each other and were positively associated with carotid IMT but negatively associated with CAVI in multivariate regression analysis. In a logistic regression analysis including CAVI and carotid IMT simultaneously, CAVI was negatively associated, but carotid IMT was positively associated, with obesity defined by each obesity-related index. In contrast, both CAVI and carotid IMT were positively associated with the presence of metabolic syndrome based on visceral fat accumulation. Conclusions: Obesity-related indices were negatively associated with CAVI and positively associated with carotid IMT in middle-aged untreated workers, while both CAVI and carotid IMT were worsened in the presence of metabolic syndrome. Japan Atherosclerosis Society 2020-04-01 /pmc/articles/PMC7192820/ /pubmed/31462618 http://dx.doi.org/10.5551/jat.50633 Text en 2020 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Original Article
Sugiura, Tomonori
Dohi, Yasuaki
Takagi, Yasuyuki
Yoshikane, Naofumi
Ito, Mitsuhisa
Suzuki, Kenji
Nagami, Takashi
Iwase, Mitsunori
Seo, Yoshihiro
Ohte, Nobuyuki
Relationships of Obesity-Related Indices and Metabolic Syndrome with Subclinical Atherosclerosis in Middle-Aged Untreated Japanese Workers
title Relationships of Obesity-Related Indices and Metabolic Syndrome with Subclinical Atherosclerosis in Middle-Aged Untreated Japanese Workers
title_full Relationships of Obesity-Related Indices and Metabolic Syndrome with Subclinical Atherosclerosis in Middle-Aged Untreated Japanese Workers
title_fullStr Relationships of Obesity-Related Indices and Metabolic Syndrome with Subclinical Atherosclerosis in Middle-Aged Untreated Japanese Workers
title_full_unstemmed Relationships of Obesity-Related Indices and Metabolic Syndrome with Subclinical Atherosclerosis in Middle-Aged Untreated Japanese Workers
title_short Relationships of Obesity-Related Indices and Metabolic Syndrome with Subclinical Atherosclerosis in Middle-Aged Untreated Japanese Workers
title_sort relationships of obesity-related indices and metabolic syndrome with subclinical atherosclerosis in middle-aged untreated japanese workers
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192820/
https://www.ncbi.nlm.nih.gov/pubmed/31462618
http://dx.doi.org/10.5551/jat.50633
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