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Expansion of Myeloid-Derived Suppressor Cells Correlates with Renal Progression in Type 2 Diabetic Nephropathy

Type 2 diabetic nephropathy (T2DN) progresses with an increasingly inflammatory milieu, wherein various immune cells are relevant. Herein, we investigated the levels of myeloid-derived suppressor cells (MDSCs) and their clinical implication in patients with T2DN. A total of 91 subjects (T2DN, n=80;...

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Autores principales: Islam, Jahirul, Lee, Hack June, Yang, Seung Hee, Kim, Dong Ki, Joo, Kwon Wook, Kim, Yon Su, Seo, Sang-Uk, Seong, Seung-Yong, Lee, Dong-Sup, Youn, Je-In, Han, Seung Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192828/
https://www.ncbi.nlm.nih.gov/pubmed/32395370
http://dx.doi.org/10.4110/in.2020.20.e18
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author Islam, Jahirul
Lee, Hack June
Yang, Seung Hee
Kim, Dong Ki
Joo, Kwon Wook
Kim, Yon Su
Seo, Sang-Uk
Seong, Seung-Yong
Lee, Dong-Sup
Youn, Je-In
Han, Seung Seok
author_facet Islam, Jahirul
Lee, Hack June
Yang, Seung Hee
Kim, Dong Ki
Joo, Kwon Wook
Kim, Yon Su
Seo, Sang-Uk
Seong, Seung-Yong
Lee, Dong-Sup
Youn, Je-In
Han, Seung Seok
author_sort Islam, Jahirul
collection PubMed
description Type 2 diabetic nephropathy (T2DN) progresses with an increasingly inflammatory milieu, wherein various immune cells are relevant. Herein, we investigated the levels of myeloid-derived suppressor cells (MDSCs) and their clinical implication in patients with T2DN. A total of 91 subjects (T2DN, n=80; healthy, n=11) were recruited and their PBMCs were used for flow cytometric analysis of polymorphonuclear (PMN-) and monocytic (M-) MDSCs, in addition to other immune cell subsets. The risk of renal progression was evaluated according to the quartiles of MDSC levels using the Cox model. The proportion of MDSCs in T2DN patients was higher than in healthy individuals (median, 6.7% vs. 2.5%). PMN-MDSCs accounted for 96% of MDSCs, and 78% of PMN-MDSCs expressed Lox-1. The expansion of PMN-MDSCs was not related to the stage of T2DN or other kidney disease parameters such as glomerular filtration rate and proteinuria. The production of ROS in PMN-MDSCs of patients was higher than in neutrophils of patients or in immune cells of healthy individuals, and this production was augmented under hyperglycemic conditions. The 4th quartile group of PMN-MDSCs had a higher risk of renal progression than the 1st quartile group, irrespective of adjusting for multiple clinical and laboratory variables. In conclusion, PMN-MDSCs are expanded in patients with T2DN, and may represent as an immunological biomarker of renal progression.
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spelling pubmed-71928282020-05-11 Expansion of Myeloid-Derived Suppressor Cells Correlates with Renal Progression in Type 2 Diabetic Nephropathy Islam, Jahirul Lee, Hack June Yang, Seung Hee Kim, Dong Ki Joo, Kwon Wook Kim, Yon Su Seo, Sang-Uk Seong, Seung-Yong Lee, Dong-Sup Youn, Je-In Han, Seung Seok Immune Netw Original Article Type 2 diabetic nephropathy (T2DN) progresses with an increasingly inflammatory milieu, wherein various immune cells are relevant. Herein, we investigated the levels of myeloid-derived suppressor cells (MDSCs) and their clinical implication in patients with T2DN. A total of 91 subjects (T2DN, n=80; healthy, n=11) were recruited and their PBMCs were used for flow cytometric analysis of polymorphonuclear (PMN-) and monocytic (M-) MDSCs, in addition to other immune cell subsets. The risk of renal progression was evaluated according to the quartiles of MDSC levels using the Cox model. The proportion of MDSCs in T2DN patients was higher than in healthy individuals (median, 6.7% vs. 2.5%). PMN-MDSCs accounted for 96% of MDSCs, and 78% of PMN-MDSCs expressed Lox-1. The expansion of PMN-MDSCs was not related to the stage of T2DN or other kidney disease parameters such as glomerular filtration rate and proteinuria. The production of ROS in PMN-MDSCs of patients was higher than in neutrophils of patients or in immune cells of healthy individuals, and this production was augmented under hyperglycemic conditions. The 4th quartile group of PMN-MDSCs had a higher risk of renal progression than the 1st quartile group, irrespective of adjusting for multiple clinical and laboratory variables. In conclusion, PMN-MDSCs are expanded in patients with T2DN, and may represent as an immunological biomarker of renal progression. The Korean Association of Immunologists 2020-02-18 /pmc/articles/PMC7192828/ /pubmed/32395370 http://dx.doi.org/10.4110/in.2020.20.e18 Text en Copyright © 2020. The Korean Association of Immunologists https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Islam, Jahirul
Lee, Hack June
Yang, Seung Hee
Kim, Dong Ki
Joo, Kwon Wook
Kim, Yon Su
Seo, Sang-Uk
Seong, Seung-Yong
Lee, Dong-Sup
Youn, Je-In
Han, Seung Seok
Expansion of Myeloid-Derived Suppressor Cells Correlates with Renal Progression in Type 2 Diabetic Nephropathy
title Expansion of Myeloid-Derived Suppressor Cells Correlates with Renal Progression in Type 2 Diabetic Nephropathy
title_full Expansion of Myeloid-Derived Suppressor Cells Correlates with Renal Progression in Type 2 Diabetic Nephropathy
title_fullStr Expansion of Myeloid-Derived Suppressor Cells Correlates with Renal Progression in Type 2 Diabetic Nephropathy
title_full_unstemmed Expansion of Myeloid-Derived Suppressor Cells Correlates with Renal Progression in Type 2 Diabetic Nephropathy
title_short Expansion of Myeloid-Derived Suppressor Cells Correlates with Renal Progression in Type 2 Diabetic Nephropathy
title_sort expansion of myeloid-derived suppressor cells correlates with renal progression in type 2 diabetic nephropathy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192828/
https://www.ncbi.nlm.nih.gov/pubmed/32395370
http://dx.doi.org/10.4110/in.2020.20.e18
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