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SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex

Sirtuin 1 (SIRT1), an NAD(+)-dependent deacetylase, is a key regulator of cellular metabolism. Recent genome-wide association studies identified genetic variants of SIRT1 linked to major depressive disorders. SIRT1 is widely expressed in the brain; however, neuronal substrates that mediate SIRT1 act...

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Detalles Bibliográficos
Autores principales:	Lei, Yun, Wang, Jiangong, Wang, Dan, Li, Chen, Liu, Bin, Fang, Xing, You, Jingjing, Guo, Ming, Lu, Xin-Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192847/ https://www.ncbi.nlm.nih.gov/pubmed/30705425 http://dx.doi.org/10.1038/s41380-019-0352-1

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