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The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC
The Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little is known about the spatial and genetic structure of the parasite population in that country. We sequence 2537 Plasmodium falciparum infections, including a nationally representative population sample from DRC...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192906/ https://www.ncbi.nlm.nih.gov/pubmed/32355199 http://dx.doi.org/10.1038/s41467-020-15779-8 |
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| author | Verity, Robert Aydemir, Ozkan Brazeau, Nicholas F. Watson, Oliver J. Hathaway, Nicholas J. Mwandagalirwa, Melchior Kashamuka Marsh, Patrick W. Thwai, Kyaw Fulton, Travis Denton, Madeline Morgan, Andrew P. Parr, Jonathan B. Tumwebaze, Patrick K. Conrad, Melissa Rosenthal, Philip J. Ishengoma, Deus S. Ngondi, Jeremiah Gutman, Julie Mulenga, Modest Norris, Douglas E. Moss, William J. Mensah, Benedicta A. Myers-Hansen, James L. Ghansah, Anita Tshefu, Antoinette K. Ghani, Azra C. Meshnick, Steven R. Bailey, Jeffrey A. Juliano, Jonathan J. |
| author_facet | Verity, Robert Aydemir, Ozkan Brazeau, Nicholas F. Watson, Oliver J. Hathaway, Nicholas J. Mwandagalirwa, Melchior Kashamuka Marsh, Patrick W. Thwai, Kyaw Fulton, Travis Denton, Madeline Morgan, Andrew P. Parr, Jonathan B. Tumwebaze, Patrick K. Conrad, Melissa Rosenthal, Philip J. Ishengoma, Deus S. Ngondi, Jeremiah Gutman, Julie Mulenga, Modest Norris, Douglas E. Moss, William J. Mensah, Benedicta A. Myers-Hansen, James L. Ghansah, Anita Tshefu, Antoinette K. Ghani, Azra C. Meshnick, Steven R. Bailey, Jeffrey A. Juliano, Jonathan J. |
| author_sort | Verity, Robert |
| collection | PubMed |
| description | The Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little is known about the spatial and genetic structure of the parasite population in that country. We sequence 2537 Plasmodium falciparum infections, including a nationally representative population sample from DRC and samples from surrounding countries, using molecular inversion probes - a high-throughput genotyping tool. We identify an east-west divide in haplotypes known to confer resistance to chloroquine and sulfadoxine-pyrimethamine. Furthermore, we identify highly related parasites over large geographic distances, indicative of gene flow and migration. Our results are consistent with a background of isolation by distance combined with the effects of selection for antimalarial drug resistance. This study provides a high-resolution view of parasite genetic structure across a large country in Africa and provides a baseline to study how implementation programs may impact parasite populations. |
| format | Online Article Text |
| id | pubmed-7192906 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71929062020-05-05 The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC Verity, Robert Aydemir, Ozkan Brazeau, Nicholas F. Watson, Oliver J. Hathaway, Nicholas J. Mwandagalirwa, Melchior Kashamuka Marsh, Patrick W. Thwai, Kyaw Fulton, Travis Denton, Madeline Morgan, Andrew P. Parr, Jonathan B. Tumwebaze, Patrick K. Conrad, Melissa Rosenthal, Philip J. Ishengoma, Deus S. Ngondi, Jeremiah Gutman, Julie Mulenga, Modest Norris, Douglas E. Moss, William J. Mensah, Benedicta A. Myers-Hansen, James L. Ghansah, Anita Tshefu, Antoinette K. Ghani, Azra C. Meshnick, Steven R. Bailey, Jeffrey A. Juliano, Jonathan J. Nat Commun Article The Democratic Republic of the Congo (DRC) harbors 11% of global malaria cases, yet little is known about the spatial and genetic structure of the parasite population in that country. We sequence 2537 Plasmodium falciparum infections, including a nationally representative population sample from DRC and samples from surrounding countries, using molecular inversion probes - a high-throughput genotyping tool. We identify an east-west divide in haplotypes known to confer resistance to chloroquine and sulfadoxine-pyrimethamine. Furthermore, we identify highly related parasites over large geographic distances, indicative of gene flow and migration. Our results are consistent with a background of isolation by distance combined with the effects of selection for antimalarial drug resistance. This study provides a high-resolution view of parasite genetic structure across a large country in Africa and provides a baseline to study how implementation programs may impact parasite populations. Nature Publishing Group UK 2020-04-30 /pmc/articles/PMC7192906/ /pubmed/32355199 http://dx.doi.org/10.1038/s41467-020-15779-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Verity, Robert Aydemir, Ozkan Brazeau, Nicholas F. Watson, Oliver J. Hathaway, Nicholas J. Mwandagalirwa, Melchior Kashamuka Marsh, Patrick W. Thwai, Kyaw Fulton, Travis Denton, Madeline Morgan, Andrew P. Parr, Jonathan B. Tumwebaze, Patrick K. Conrad, Melissa Rosenthal, Philip J. Ishengoma, Deus S. Ngondi, Jeremiah Gutman, Julie Mulenga, Modest Norris, Douglas E. Moss, William J. Mensah, Benedicta A. Myers-Hansen, James L. Ghansah, Anita Tshefu, Antoinette K. Ghani, Azra C. Meshnick, Steven R. Bailey, Jeffrey A. Juliano, Jonathan J. The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC |
| title | The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC |
| title_full | The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC |
| title_fullStr | The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC |
| title_full_unstemmed | The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC |
| title_short | The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC |
| title_sort | impact of antimalarial resistance on the genetic structure of plasmodium falciparum in the drc |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192906/ https://www.ncbi.nlm.nih.gov/pubmed/32355199 http://dx.doi.org/10.1038/s41467-020-15779-8 |
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