Systemic Delivery of siRNA Specific for Silencing TLR4 Gene Expression Reduces Diabetic Cardiomyopathy in a Mouse Model of Streptozotocin-Induced Type 1 Diabetes

INTRODUCTION: Diabetic cardiomyopathy is a cardiac dysfunction in patients with diabetes which may lead to overt heart failure and death. Toll-like receptor (TLR) signaling triggers diabetic cardiomyopathy through various mechanisms, one of which is the upregulation of TLR4 expression. The aim of th...

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Detalles Bibliográficos
Autores principales: Zhang, Yuwei, Li, Yang, Huang, Xuefang, Zhang, Fang, Tang, Lizhi, Xu, Shishi, Liu, Yuqi, Tong, Nanwei, Min, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193037/
https://www.ncbi.nlm.nih.gov/pubmed/32285313
http://dx.doi.org/10.1007/s13300-020-00802-4

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