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High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD
Overconsumption of carbohydrates and lipids are well known to cause nonalcoholic fatty liver disease (NAFLD), while the role of nutritional protein intake is less clear. In Western diet, meat and other animal products are the main protein source, with varying concentrations of specific amino acids....
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193126/ https://www.ncbi.nlm.nih.gov/pubmed/32363319 http://dx.doi.org/10.1002/hep4.1509 |
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author | Lang, Sonja Martin, Anna Farowski, Fedja Wisplinghoff, Hilmar Vehreschild, Maria J.G.T. Liu, Jinyuan Krawczyk, Marcin Nowag, Angela Kretzschmar, Anne Herweg, Jens Schnabl, Bernd Tu, Xin M. Lammert, Frank Goeser, Tobias Tacke, Frank Heinzer, Kathrin Kasper, Philipp Steffen, Hans‐Michael Demir, Münevver |
author_facet | Lang, Sonja Martin, Anna Farowski, Fedja Wisplinghoff, Hilmar Vehreschild, Maria J.G.T. Liu, Jinyuan Krawczyk, Marcin Nowag, Angela Kretzschmar, Anne Herweg, Jens Schnabl, Bernd Tu, Xin M. Lammert, Frank Goeser, Tobias Tacke, Frank Heinzer, Kathrin Kasper, Philipp Steffen, Hans‐Michael Demir, Münevver |
author_sort | Lang, Sonja |
collection | PubMed |
description | Overconsumption of carbohydrates and lipids are well known to cause nonalcoholic fatty liver disease (NAFLD), while the role of nutritional protein intake is less clear. In Western diet, meat and other animal products are the main protein source, with varying concentrations of specific amino acids. Whether the amount or composition of protein intake is associated with a higher risk for disease severity has not yet been examined. In this study, we investigated associations of dietary components with histological disease activity by analyzing detailed 14‐day food records in a cohort of 61 patients with biopsy‐proven NAFLD. Furthermore, we used 16S ribosomal RNA gene sequencing to detect associations with different abundances of the gut microbiota with dietary patterns. Patients with definite nonalcoholic steatohepatitis (NAFLD activity score of 5‐8 on liver biopsy) had a significantly higher daily relative intake of protein compared with patients with a NAFLD activity score of 0‐4 (18.0% vs. 15.8% of daily protein‐based calories, P = 0.018). After adjustment for several potentially confounding factors, a higher protein intake (≥17.3% of daily protein‐based calories) remained associated with definite nonalcoholic steatohepatitis, with an odds ratio of 5.09 (95% confidence interval 1.22‐21.25, P = 0.026). This association was driven primarily by serine, glycine, arginine, proline, phenylalanine, and methionine. A higher protein intake correlated with a lower Bacteroides abundance and an altered abundance of several other bacterial taxa. Conclusion: A high protein intake was independently associated with more active and severe histological disease activity in patients with NAFLD. Further studies are needed to investigate the potential harmful role of dietary amino acids on NAFLD, with special attention to meat as their major source. |
format | Online Article Text |
id | pubmed-7193126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71931262020-05-01 High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD Lang, Sonja Martin, Anna Farowski, Fedja Wisplinghoff, Hilmar Vehreschild, Maria J.G.T. Liu, Jinyuan Krawczyk, Marcin Nowag, Angela Kretzschmar, Anne Herweg, Jens Schnabl, Bernd Tu, Xin M. Lammert, Frank Goeser, Tobias Tacke, Frank Heinzer, Kathrin Kasper, Philipp Steffen, Hans‐Michael Demir, Münevver Hepatol Commun Original Articles Overconsumption of carbohydrates and lipids are well known to cause nonalcoholic fatty liver disease (NAFLD), while the role of nutritional protein intake is less clear. In Western diet, meat and other animal products are the main protein source, with varying concentrations of specific amino acids. Whether the amount or composition of protein intake is associated with a higher risk for disease severity has not yet been examined. In this study, we investigated associations of dietary components with histological disease activity by analyzing detailed 14‐day food records in a cohort of 61 patients with biopsy‐proven NAFLD. Furthermore, we used 16S ribosomal RNA gene sequencing to detect associations with different abundances of the gut microbiota with dietary patterns. Patients with definite nonalcoholic steatohepatitis (NAFLD activity score of 5‐8 on liver biopsy) had a significantly higher daily relative intake of protein compared with patients with a NAFLD activity score of 0‐4 (18.0% vs. 15.8% of daily protein‐based calories, P = 0.018). After adjustment for several potentially confounding factors, a higher protein intake (≥17.3% of daily protein‐based calories) remained associated with definite nonalcoholic steatohepatitis, with an odds ratio of 5.09 (95% confidence interval 1.22‐21.25, P = 0.026). This association was driven primarily by serine, glycine, arginine, proline, phenylalanine, and methionine. A higher protein intake correlated with a lower Bacteroides abundance and an altered abundance of several other bacterial taxa. Conclusion: A high protein intake was independently associated with more active and severe histological disease activity in patients with NAFLD. Further studies are needed to investigate the potential harmful role of dietary amino acids on NAFLD, with special attention to meat as their major source. John Wiley and Sons Inc. 2020-03-26 /pmc/articles/PMC7193126/ /pubmed/32363319 http://dx.doi.org/10.1002/hep4.1509 Text en © 2020 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Lang, Sonja Martin, Anna Farowski, Fedja Wisplinghoff, Hilmar Vehreschild, Maria J.G.T. Liu, Jinyuan Krawczyk, Marcin Nowag, Angela Kretzschmar, Anne Herweg, Jens Schnabl, Bernd Tu, Xin M. Lammert, Frank Goeser, Tobias Tacke, Frank Heinzer, Kathrin Kasper, Philipp Steffen, Hans‐Michael Demir, Münevver High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD |
title | High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD |
title_full | High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD |
title_fullStr | High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD |
title_full_unstemmed | High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD |
title_short | High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD |
title_sort | high protein intake is associated with histological disease activity in patients with nafld |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193126/ https://www.ncbi.nlm.nih.gov/pubmed/32363319 http://dx.doi.org/10.1002/hep4.1509 |
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