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Down‐regulation of anti‐inflammatory TIPE2 may aggravate adenoidal hypertrophy in children

Adenoidal hypertrophy (AH) is a common disorder in the pediatric population, with common symptoms including mouth breathing, nasal congestion, hyponasal speech, snoring and obstructive sleep apnea. Although the pathogenesis of AH has not been fully elucidated, recent studies have indicated that immu...

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Autores principales: Gao, Kun, Li, Yanzhong, Yue, Zhiyong, Han, Jie, Zhou, Xuanchen, Wang, Xiaoting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193160/
https://www.ncbi.nlm.nih.gov/pubmed/32100476
http://dx.doi.org/10.1002/2211-5463.12821
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author Gao, Kun
Li, Yanzhong
Yue, Zhiyong
Han, Jie
Zhou, Xuanchen
Wang, Xiaoting
author_facet Gao, Kun
Li, Yanzhong
Yue, Zhiyong
Han, Jie
Zhou, Xuanchen
Wang, Xiaoting
author_sort Gao, Kun
collection PubMed
description Adenoidal hypertrophy (AH) is a common disorder in the pediatric population, with common symptoms including mouth breathing, nasal congestion, hyponasal speech, snoring and obstructive sleep apnea. Although the pathogenesis of AH has not been fully elucidated, recent studies have indicated that immune responses may play an important role in AH. Tumor necrosis factor‐alpha (TNF‐α)‐induced protein‐8 like‐2 (TIPE2) is a newly identified protein that negatively regulates the activation of inflammatory pathways. Here, we investigated the effect of TIPE2 in AH in children. We observed that the levels of TNF‐α and interleukin‐6 were greater in the adenoid tissue of AH children than in healthy control subjects (P < 0.01), and this increase was positively correlated with the severity of AH. The level of TIPE2 expression was decreased compared with control and was negatively correlated with AH. TIPE2 overexpression in primary human monocytes (isolated from adenoid tissue of children with AH) inhibited the activation of nuclear factor‐κB and the expression of TNF‐α and interleukin‐6. These results suggest that overexpression of TIPE2 may attenuate AH through inactivation of the nuclear factor‐κB signaling pathway.
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spelling pubmed-71931602020-05-01 Down‐regulation of anti‐inflammatory TIPE2 may aggravate adenoidal hypertrophy in children Gao, Kun Li, Yanzhong Yue, Zhiyong Han, Jie Zhou, Xuanchen Wang, Xiaoting FEBS Open Bio Research Articles Adenoidal hypertrophy (AH) is a common disorder in the pediatric population, with common symptoms including mouth breathing, nasal congestion, hyponasal speech, snoring and obstructive sleep apnea. Although the pathogenesis of AH has not been fully elucidated, recent studies have indicated that immune responses may play an important role in AH. Tumor necrosis factor‐alpha (TNF‐α)‐induced protein‐8 like‐2 (TIPE2) is a newly identified protein that negatively regulates the activation of inflammatory pathways. Here, we investigated the effect of TIPE2 in AH in children. We observed that the levels of TNF‐α and interleukin‐6 were greater in the adenoid tissue of AH children than in healthy control subjects (P < 0.01), and this increase was positively correlated with the severity of AH. The level of TIPE2 expression was decreased compared with control and was negatively correlated with AH. TIPE2 overexpression in primary human monocytes (isolated from adenoid tissue of children with AH) inhibited the activation of nuclear factor‐κB and the expression of TNF‐α and interleukin‐6. These results suggest that overexpression of TIPE2 may attenuate AH through inactivation of the nuclear factor‐κB signaling pathway. John Wiley and Sons Inc. 2020-03-22 /pmc/articles/PMC7193160/ /pubmed/32100476 http://dx.doi.org/10.1002/2211-5463.12821 Text en © 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Gao, Kun
Li, Yanzhong
Yue, Zhiyong
Han, Jie
Zhou, Xuanchen
Wang, Xiaoting
Down‐regulation of anti‐inflammatory TIPE2 may aggravate adenoidal hypertrophy in children
title Down‐regulation of anti‐inflammatory TIPE2 may aggravate adenoidal hypertrophy in children
title_full Down‐regulation of anti‐inflammatory TIPE2 may aggravate adenoidal hypertrophy in children
title_fullStr Down‐regulation of anti‐inflammatory TIPE2 may aggravate adenoidal hypertrophy in children
title_full_unstemmed Down‐regulation of anti‐inflammatory TIPE2 may aggravate adenoidal hypertrophy in children
title_short Down‐regulation of anti‐inflammatory TIPE2 may aggravate adenoidal hypertrophy in children
title_sort down‐regulation of anti‐inflammatory tipe2 may aggravate adenoidal hypertrophy in children
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193160/
https://www.ncbi.nlm.nih.gov/pubmed/32100476
http://dx.doi.org/10.1002/2211-5463.12821
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