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A biphasic tumor in posterior cranial fossa and the pineal region in young adult
BACKGROUND: Biphasic tumors of the central nervous system are rarely described and mainly consisted out of the glial and mesenchymal component. The tumor originated out of both astrocytes and pinealocytes, best to our knowledge, has not been described. We present a case of a brain tumor consisted ou...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Scientific Scholar
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193197/ https://www.ncbi.nlm.nih.gov/pubmed/32363059 http://dx.doi.org/10.25259/SNI_288_2019 |
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author | Almahariq, Fadi Raguz, Marina Romic, Dominik Dlaka, Domagoj Oreskovic, Darko Sesar, Patricija Chudy, Darko |
author_facet | Almahariq, Fadi Raguz, Marina Romic, Dominik Dlaka, Domagoj Oreskovic, Darko Sesar, Patricija Chudy, Darko |
author_sort | Almahariq, Fadi |
collection | PubMed |
description | BACKGROUND: Biphasic tumors of the central nervous system are rarely described and mainly consisted out of the glial and mesenchymal component. The tumor originated out of both astrocytes and pinealocytes, best to our knowledge, has not been described. We present a case of a brain tumor consisted out of pilocytic astrocytoma (PA) and pineocytoma as components situated in the pineal region and posterior cranial fossa in young adult. CASE DESCRIPTION: We present a 21-year-old patient with a history of intermittent headache, followed by nausea and vomiting, double vision, and dextropulsion. Magnetic resonance imaging revealed an extensive cystic-solid expansive formation in the posterior cranial fossa with a solid part in the area of the pineal gland. The patient underwent surgical resection. The pathohistological analysis showed two types of tumor cells; the major part of tumor showed features of PA, while minor part corresponded to pineocytoma. CONCLUSION: PA accounts for 5% of all gliomas and is most common in children and young adults. It usually occurs in the cerebellum, the optic pathway, third ventricular region, etc. Pineocytomas are rare, accounting up to 1% of all intracranial tumors. Since tumors origin is different, there must be complex molecular events or mutations that can lead to cell rearrangements and generation of two histologically different tissues in the same tumor mass. The course of treatment options is different for PA and pineocytoma; therefore, the case of brain mass consisted out of two different tissues can be helpful when deciding about the treatment of tumors in posterior cranial fossa and pineal region. |
format | Online Article Text |
id | pubmed-7193197 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Scientific Scholar |
record_format | MEDLINE/PubMed |
spelling | pubmed-71931972020-05-01 A biphasic tumor in posterior cranial fossa and the pineal region in young adult Almahariq, Fadi Raguz, Marina Romic, Dominik Dlaka, Domagoj Oreskovic, Darko Sesar, Patricija Chudy, Darko Surg Neurol Int Case Report BACKGROUND: Biphasic tumors of the central nervous system are rarely described and mainly consisted out of the glial and mesenchymal component. The tumor originated out of both astrocytes and pinealocytes, best to our knowledge, has not been described. We present a case of a brain tumor consisted out of pilocytic astrocytoma (PA) and pineocytoma as components situated in the pineal region and posterior cranial fossa in young adult. CASE DESCRIPTION: We present a 21-year-old patient with a history of intermittent headache, followed by nausea and vomiting, double vision, and dextropulsion. Magnetic resonance imaging revealed an extensive cystic-solid expansive formation in the posterior cranial fossa with a solid part in the area of the pineal gland. The patient underwent surgical resection. The pathohistological analysis showed two types of tumor cells; the major part of tumor showed features of PA, while minor part corresponded to pineocytoma. CONCLUSION: PA accounts for 5% of all gliomas and is most common in children and young adults. It usually occurs in the cerebellum, the optic pathway, third ventricular region, etc. Pineocytomas are rare, accounting up to 1% of all intracranial tumors. Since tumors origin is different, there must be complex molecular events or mutations that can lead to cell rearrangements and generation of two histologically different tissues in the same tumor mass. The course of treatment options is different for PA and pineocytoma; therefore, the case of brain mass consisted out of two different tissues can be helpful when deciding about the treatment of tumors in posterior cranial fossa and pineal region. Scientific Scholar 2020-04-11 /pmc/articles/PMC7193197/ /pubmed/32363059 http://dx.doi.org/10.25259/SNI_288_2019 Text en Copyright: © 2020 Surgical Neurology International http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Almahariq, Fadi Raguz, Marina Romic, Dominik Dlaka, Domagoj Oreskovic, Darko Sesar, Patricija Chudy, Darko A biphasic tumor in posterior cranial fossa and the pineal region in young adult |
title | A biphasic tumor in posterior cranial fossa and the pineal region in young adult |
title_full | A biphasic tumor in posterior cranial fossa and the pineal region in young adult |
title_fullStr | A biphasic tumor in posterior cranial fossa and the pineal region in young adult |
title_full_unstemmed | A biphasic tumor in posterior cranial fossa and the pineal region in young adult |
title_short | A biphasic tumor in posterior cranial fossa and the pineal region in young adult |
title_sort | biphasic tumor in posterior cranial fossa and the pineal region in young adult |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193197/ https://www.ncbi.nlm.nih.gov/pubmed/32363059 http://dx.doi.org/10.25259/SNI_288_2019 |
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