First Preliminary Experience with Preservation of Liver Grafts from Extended-Criteria Donors by Normothermic Machine Perfusion in Asia

BACKGROUND: Normothermic machine perfusion (NMP) can provide access to evaluate and resuscitate high-risk donor livers before transplantation. The purpose of this study was to determine the efficacy of NMP in preservation and assessment of extended-criteria donor (ECD) livers in China. CASE REPORTS:...

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Detalles Bibliográficos
Autores principales: Zhang, Zhiheng, Ju, Weiqiang, Tang, Yunhua, Wang, Linhe, Zhu, Caihui, Gao, Ningxin, Zhao, Qiang, Huang, Shanzhou, Wang, Dongping, Yang, Lu, Han, Ming, Xiong, Wei, Wu, Linwei, Chen, Maogen, Zhang, Yixi, Zhu, Yanling, Sun, Chengjun, Zhu, Xiaofeng, Guo, Zhiyong, He, Xiaoshun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193227/
https://www.ncbi.nlm.nih.gov/pubmed/32312947
http://dx.doi.org/10.12659/AOT.921529
Descripción
Sumario:BACKGROUND: Normothermic machine perfusion (NMP) can provide access to evaluate and resuscitate high-risk donor livers before transplantation. The purpose of this study was to determine the efficacy of NMP in preservation and assessment of extended-criteria donor (ECD) livers in China. CASE REPORTS: From September 2018 to March 2019, 4 liver grafts from 3 transplant center defined as ECD were subjected to NMP, and then were transplanted successfully. During perfusion, perfusion parameters such as vascular flow, glucose level, lactate clearance, and bile production/composition were recorded to assess graft viability. All recipients were followed up 6 months after transplantation. CONCLUSIONS: NMP provides a potential tool for preservation and assessment of ECD livers in China.

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