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Maternal PM(2.5) exposure triggers preterm birth: a cross-sectional study in Wuhan, China
BACKGROUND: Most of the studies regarding air pollution and preterm birth (PTB) in highly polluted areas have estimated the exposure level based on fixed-site monitoring. However, exposure assessment methods relying on monitors have the potential to cause exposure misclassification due to a lack of...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193342/ https://www.ncbi.nlm.nih.gov/pubmed/32377568 http://dx.doi.org/10.1186/s41256-020-00144-5 |
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author | Zhang, Xiaotong Fan, Cuifang Ren, Zhan Feng, Huan Zuo, Shanshan Hao, Jiayuan Liao, Jingling Zou, Yuliang Ma, Lu |
author_facet | Zhang, Xiaotong Fan, Cuifang Ren, Zhan Feng, Huan Zuo, Shanshan Hao, Jiayuan Liao, Jingling Zou, Yuliang Ma, Lu |
author_sort | Zhang, Xiaotong |
collection | PubMed |
description | BACKGROUND: Most of the studies regarding air pollution and preterm birth (PTB) in highly polluted areas have estimated the exposure level based on fixed-site monitoring. However, exposure assessment methods relying on monitors have the potential to cause exposure misclassification due to a lack of spatial variation. In this study, we utilized a land use regression (LUR) model to assess individual exposure, and explored the association between PM(2.5) exposure during each time window and the risk of preterm birth in Wuhan city, China. METHODS: Information on 2101 singleton births, which were ≥ 20 weeks of gestation and born between November 1, 2013 and May 31, 2014; between January 1, 2015 and August 31, 2015, was obtained from the Obstetrics Department in one 3A hospital in Wuhan. Air quality index (AQI) data were accessed from the Wuhan Environmental Protection Bureau website. Individual exposure during pregnancy was assessed by LUR models and Kriging interpolation. Logistic regression analyses were conducted to determine the association between women exposure to PM(2.5) and the risk of different subtypes of PTB. RESULTS: During the study period, the average individual exposure concentration of PM(2.5) during the entire pregnancy was 84.54 μg/m(3). A 10 μg/m(3) increase of PM(2.5) exposure in the first trimester (OR: 1.169; 95% CI: 1.077, 1.262), the second trimester (OR: 1.056; 95% CI: 1.015, 1.097), the third trimester (OR: 1.052; 95% CI: 1.002, 1.101), and the entire pregnancy (OR: 1.263; 95% CI: 1.158, 1.368) was significantly associated with an increased risk of PTB. For the PTB subgroup, the hazard of PM(2.5) exposure during pregnancy was stronger for very preterm births (VPTB) than moderate preterm births (MPTB). The first trimester was the most susceptible exposure window. Moreover, women who had less than 9 years of education or who conceived during the cold season tended to be more susceptible to the PM(2.5) exposure during pregnancy. CONCLUSIONS: Maternal exposure to PM(2.5) increased the risk of PTB, and this risk was stronger for VPTB than for MPTB, especially during the first trimester. |
format | Online Article Text |
id | pubmed-7193342 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-71933422020-05-06 Maternal PM(2.5) exposure triggers preterm birth: a cross-sectional study in Wuhan, China Zhang, Xiaotong Fan, Cuifang Ren, Zhan Feng, Huan Zuo, Shanshan Hao, Jiayuan Liao, Jingling Zou, Yuliang Ma, Lu Glob Health Res Policy Research BACKGROUND: Most of the studies regarding air pollution and preterm birth (PTB) in highly polluted areas have estimated the exposure level based on fixed-site monitoring. However, exposure assessment methods relying on monitors have the potential to cause exposure misclassification due to a lack of spatial variation. In this study, we utilized a land use regression (LUR) model to assess individual exposure, and explored the association between PM(2.5) exposure during each time window and the risk of preterm birth in Wuhan city, China. METHODS: Information on 2101 singleton births, which were ≥ 20 weeks of gestation and born between November 1, 2013 and May 31, 2014; between January 1, 2015 and August 31, 2015, was obtained from the Obstetrics Department in one 3A hospital in Wuhan. Air quality index (AQI) data were accessed from the Wuhan Environmental Protection Bureau website. Individual exposure during pregnancy was assessed by LUR models and Kriging interpolation. Logistic regression analyses were conducted to determine the association between women exposure to PM(2.5) and the risk of different subtypes of PTB. RESULTS: During the study period, the average individual exposure concentration of PM(2.5) during the entire pregnancy was 84.54 μg/m(3). A 10 μg/m(3) increase of PM(2.5) exposure in the first trimester (OR: 1.169; 95% CI: 1.077, 1.262), the second trimester (OR: 1.056; 95% CI: 1.015, 1.097), the third trimester (OR: 1.052; 95% CI: 1.002, 1.101), and the entire pregnancy (OR: 1.263; 95% CI: 1.158, 1.368) was significantly associated with an increased risk of PTB. For the PTB subgroup, the hazard of PM(2.5) exposure during pregnancy was stronger for very preterm births (VPTB) than moderate preterm births (MPTB). The first trimester was the most susceptible exposure window. Moreover, women who had less than 9 years of education or who conceived during the cold season tended to be more susceptible to the PM(2.5) exposure during pregnancy. CONCLUSIONS: Maternal exposure to PM(2.5) increased the risk of PTB, and this risk was stronger for VPTB than for MPTB, especially during the first trimester. BioMed Central 2020-05-01 /pmc/articles/PMC7193342/ /pubmed/32377568 http://dx.doi.org/10.1186/s41256-020-00144-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Zhang, Xiaotong Fan, Cuifang Ren, Zhan Feng, Huan Zuo, Shanshan Hao, Jiayuan Liao, Jingling Zou, Yuliang Ma, Lu Maternal PM(2.5) exposure triggers preterm birth: a cross-sectional study in Wuhan, China |
title | Maternal PM(2.5) exposure triggers preterm birth: a cross-sectional study in Wuhan, China |
title_full | Maternal PM(2.5) exposure triggers preterm birth: a cross-sectional study in Wuhan, China |
title_fullStr | Maternal PM(2.5) exposure triggers preterm birth: a cross-sectional study in Wuhan, China |
title_full_unstemmed | Maternal PM(2.5) exposure triggers preterm birth: a cross-sectional study in Wuhan, China |
title_short | Maternal PM(2.5) exposure triggers preterm birth: a cross-sectional study in Wuhan, China |
title_sort | maternal pm(2.5) exposure triggers preterm birth: a cross-sectional study in wuhan, china |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193342/ https://www.ncbi.nlm.nih.gov/pubmed/32377568 http://dx.doi.org/10.1186/s41256-020-00144-5 |
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