Correlation of gene polymorphisms of vascular endothelial growth factor with grade and prognosis of lung cancer

BACKGROUND: Vascular endothelial growth factor (VEGF) gene is highly polymorphic, and single nucleotide polymorphisms (SNP) of VEGF gene are associate with cancer prognosis. This study aimed to analyze the correlation of VEGF gene polymorphisms with grade and prognosis of lung cancer. METHODS: A tot...

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Autores principales: Liu, Changjiang, Zhou, Xuetao, Zhang, Zefeng, Guo, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193393/
https://www.ncbi.nlm.nih.gov/pubmed/32354326
http://dx.doi.org/10.1186/s12881-020-01030-0
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author Liu, Changjiang
Zhou, Xuetao
Zhang, Zefeng
Guo, Yang
author_facet Liu, Changjiang
Zhou, Xuetao
Zhang, Zefeng
Guo, Yang
author_sort Liu, Changjiang
collection PubMed
description BACKGROUND: Vascular endothelial growth factor (VEGF) gene is highly polymorphic, and single nucleotide polymorphisms (SNP) of VEGF gene are associate with cancer prognosis. This study aimed to analyze the correlation of VEGF gene polymorphisms with grade and prognosis of lung cancer. METHODS: A total of 458 Chinese patients with primary lung cancer were enrolled from September 2008 to October 2013. The genotypes of −2578C > A, −1154G > A, − 460 T > C, and + 405G > C were analyzed in white blood cells from patients using polymerase chain reaction based restriction fragment length polymorphism. RESULTS: Our data showed that –1154G > A polymorphism was significantly associated with tumor stages, but all four tested VEGF gene polymorphisms had no significant effect on survival. CONCLUSIONS: VEGF polymorphisms may relate to stage of lung cancer in Chinese population.
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spelling pubmed-71933932020-05-06 Correlation of gene polymorphisms of vascular endothelial growth factor with grade and prognosis of lung cancer Liu, Changjiang Zhou, Xuetao Zhang, Zefeng Guo, Yang BMC Med Genet Research Article BACKGROUND: Vascular endothelial growth factor (VEGF) gene is highly polymorphic, and single nucleotide polymorphisms (SNP) of VEGF gene are associate with cancer prognosis. This study aimed to analyze the correlation of VEGF gene polymorphisms with grade and prognosis of lung cancer. METHODS: A total of 458 Chinese patients with primary lung cancer were enrolled from September 2008 to October 2013. The genotypes of −2578C > A, −1154G > A, − 460 T > C, and + 405G > C were analyzed in white blood cells from patients using polymerase chain reaction based restriction fragment length polymorphism. RESULTS: Our data showed that –1154G > A polymorphism was significantly associated with tumor stages, but all four tested VEGF gene polymorphisms had no significant effect on survival. CONCLUSIONS: VEGF polymorphisms may relate to stage of lung cancer in Chinese population. BioMed Central 2020-04-30 /pmc/articles/PMC7193393/ /pubmed/32354326 http://dx.doi.org/10.1186/s12881-020-01030-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Liu, Changjiang
Zhou, Xuetao
Zhang, Zefeng
Guo, Yang
Correlation of gene polymorphisms of vascular endothelial growth factor with grade and prognosis of lung cancer
title Correlation of gene polymorphisms of vascular endothelial growth factor with grade and prognosis of lung cancer
title_full Correlation of gene polymorphisms of vascular endothelial growth factor with grade and prognosis of lung cancer
title_fullStr Correlation of gene polymorphisms of vascular endothelial growth factor with grade and prognosis of lung cancer
title_full_unstemmed Correlation of gene polymorphisms of vascular endothelial growth factor with grade and prognosis of lung cancer
title_short Correlation of gene polymorphisms of vascular endothelial growth factor with grade and prognosis of lung cancer
title_sort correlation of gene polymorphisms of vascular endothelial growth factor with grade and prognosis of lung cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193393/
https://www.ncbi.nlm.nih.gov/pubmed/32354326
http://dx.doi.org/10.1186/s12881-020-01030-0
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AT zhangzefeng correlationofgenepolymorphismsofvascularendothelialgrowthfactorwithgradeandprognosisoflungcancer
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