Cargando…
Predicting Ectopic Pregnancy Using Human Chorionic Gonadotropin (hCG) Levels and Main Cause of Infertility in Women Undergoing Assisted Reproductive Treatment: Retrospective Observational Cohort Study
BACKGROUND: Ectopic pregnancy (EP) is a serious complication of assisted reproductive technology (ART). However, there is no acknowledged mathematical model for predicting EP in the ART population. OBJECTIVE: The goal of the research was to establish a model to tailor treatment for women with a high...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JMIR Publications
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193436/ https://www.ncbi.nlm.nih.gov/pubmed/32297865 http://dx.doi.org/10.2196/17366 |
_version_ | 1783528197589041152 |
---|---|
author | Xu, Huiyu Feng, Guoshuang Wei, Yuan Feng, Ying Yang, Rui Wang, Liying Zhang, Hongxia Li, Rong Qiao, Jie |
author_facet | Xu, Huiyu Feng, Guoshuang Wei, Yuan Feng, Ying Yang, Rui Wang, Liying Zhang, Hongxia Li, Rong Qiao, Jie |
author_sort | Xu, Huiyu |
collection | PubMed |
description | BACKGROUND: Ectopic pregnancy (EP) is a serious complication of assisted reproductive technology (ART). However, there is no acknowledged mathematical model for predicting EP in the ART population. OBJECTIVE: The goal of the research was to establish a model to tailor treatment for women with a higher risk of EP. METHODS: From December 2015 to July 2016, we retrospectively included 1703 women whose serum human chorionic gonadotropin (hCG) levels were positive on day 21 (hCG21) after fresh embryo transfer. Multivariable multinomial logistic regression was used to predict EP, intrauterine pregnancy (IUP), and biochemical pregnancy (BCP). RESULTS: The variables included in the final predicting model were (hCG21, ratio of hCG21/hCG14, and main cause of infertility). During evaluation of the model, the areas under the receiver operating curve for IUP, EP, and BCP were 0.978, 0.962, and 0.999, respectively, in the training set, and 0.963, 0.942, and 0.996, respectively, in the validation set. The misclassification rates were 0.038 and 0.045, respectively, in the training and validation sets. Our model classified the whole in vitro fertilization/intracytoplasmic sperm injection–embryo transfer population into four groups: first, the low-risk EP group, with incidence of EP of 0.52% (0.23%-1.03%); second, a predicted BCP group, with incidence of EP of 5.79% (1.21%-15.95%); third, a predicted undetermined group, with incidence of EP of 28.32% (21.10%-35.53%), and fourth, a predicted high-risk EP group, with incidence of EP of 64.11% (47.22%-78.81%). CONCLUSIONS: We have established a model to sort the women undergoing ART into four groups according to their incidence of EP in order to reduce the medical resources spent on women with low-risk EP and provide targeted tailor-made treatment for women with a higher risk of EP. |
format | Online Article Text |
id | pubmed-7193436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | JMIR Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-71934362020-05-05 Predicting Ectopic Pregnancy Using Human Chorionic Gonadotropin (hCG) Levels and Main Cause of Infertility in Women Undergoing Assisted Reproductive Treatment: Retrospective Observational Cohort Study Xu, Huiyu Feng, Guoshuang Wei, Yuan Feng, Ying Yang, Rui Wang, Liying Zhang, Hongxia Li, Rong Qiao, Jie JMIR Med Inform Original Paper BACKGROUND: Ectopic pregnancy (EP) is a serious complication of assisted reproductive technology (ART). However, there is no acknowledged mathematical model for predicting EP in the ART population. OBJECTIVE: The goal of the research was to establish a model to tailor treatment for women with a higher risk of EP. METHODS: From December 2015 to July 2016, we retrospectively included 1703 women whose serum human chorionic gonadotropin (hCG) levels were positive on day 21 (hCG21) after fresh embryo transfer. Multivariable multinomial logistic regression was used to predict EP, intrauterine pregnancy (IUP), and biochemical pregnancy (BCP). RESULTS: The variables included in the final predicting model were (hCG21, ratio of hCG21/hCG14, and main cause of infertility). During evaluation of the model, the areas under the receiver operating curve for IUP, EP, and BCP were 0.978, 0.962, and 0.999, respectively, in the training set, and 0.963, 0.942, and 0.996, respectively, in the validation set. The misclassification rates were 0.038 and 0.045, respectively, in the training and validation sets. Our model classified the whole in vitro fertilization/intracytoplasmic sperm injection–embryo transfer population into four groups: first, the low-risk EP group, with incidence of EP of 0.52% (0.23%-1.03%); second, a predicted BCP group, with incidence of EP of 5.79% (1.21%-15.95%); third, a predicted undetermined group, with incidence of EP of 28.32% (21.10%-35.53%), and fourth, a predicted high-risk EP group, with incidence of EP of 64.11% (47.22%-78.81%). CONCLUSIONS: We have established a model to sort the women undergoing ART into four groups according to their incidence of EP in order to reduce the medical resources spent on women with low-risk EP and provide targeted tailor-made treatment for women with a higher risk of EP. JMIR Publications 2020-04-16 /pmc/articles/PMC7193436/ /pubmed/32297865 http://dx.doi.org/10.2196/17366 Text en ©Huiyu Xu, Guoshuang Feng, Yuan Wei, Ying Feng, Rui Yang, Liying Wang, Hongxia Zhang, Rong Li, Jie Qiao. Originally published in JMIR Medical Informatics (http://medinform.jmir.org), 16.04.2020. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Medical Informatics, is properly cited. The complete bibliographic information, a link to the original publication on http://medinform.jmir.org/, as well as this copyright and license information must be included. |
spellingShingle | Original Paper Xu, Huiyu Feng, Guoshuang Wei, Yuan Feng, Ying Yang, Rui Wang, Liying Zhang, Hongxia Li, Rong Qiao, Jie Predicting Ectopic Pregnancy Using Human Chorionic Gonadotropin (hCG) Levels and Main Cause of Infertility in Women Undergoing Assisted Reproductive Treatment: Retrospective Observational Cohort Study |
title | Predicting Ectopic Pregnancy Using Human Chorionic Gonadotropin (hCG) Levels and Main Cause of Infertility in Women Undergoing Assisted Reproductive Treatment: Retrospective Observational Cohort Study |
title_full | Predicting Ectopic Pregnancy Using Human Chorionic Gonadotropin (hCG) Levels and Main Cause of Infertility in Women Undergoing Assisted Reproductive Treatment: Retrospective Observational Cohort Study |
title_fullStr | Predicting Ectopic Pregnancy Using Human Chorionic Gonadotropin (hCG) Levels and Main Cause of Infertility in Women Undergoing Assisted Reproductive Treatment: Retrospective Observational Cohort Study |
title_full_unstemmed | Predicting Ectopic Pregnancy Using Human Chorionic Gonadotropin (hCG) Levels and Main Cause of Infertility in Women Undergoing Assisted Reproductive Treatment: Retrospective Observational Cohort Study |
title_short | Predicting Ectopic Pregnancy Using Human Chorionic Gonadotropin (hCG) Levels and Main Cause of Infertility in Women Undergoing Assisted Reproductive Treatment: Retrospective Observational Cohort Study |
title_sort | predicting ectopic pregnancy using human chorionic gonadotropin (hcg) levels and main cause of infertility in women undergoing assisted reproductive treatment: retrospective observational cohort study |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193436/ https://www.ncbi.nlm.nih.gov/pubmed/32297865 http://dx.doi.org/10.2196/17366 |
work_keys_str_mv | AT xuhuiyu predictingectopicpregnancyusinghumanchorionicgonadotropinhcglevelsandmaincauseofinfertilityinwomenundergoingassistedreproductivetreatmentretrospectiveobservationalcohortstudy AT fengguoshuang predictingectopicpregnancyusinghumanchorionicgonadotropinhcglevelsandmaincauseofinfertilityinwomenundergoingassistedreproductivetreatmentretrospectiveobservationalcohortstudy AT weiyuan predictingectopicpregnancyusinghumanchorionicgonadotropinhcglevelsandmaincauseofinfertilityinwomenundergoingassistedreproductivetreatmentretrospectiveobservationalcohortstudy AT fengying predictingectopicpregnancyusinghumanchorionicgonadotropinhcglevelsandmaincauseofinfertilityinwomenundergoingassistedreproductivetreatmentretrospectiveobservationalcohortstudy AT yangrui predictingectopicpregnancyusinghumanchorionicgonadotropinhcglevelsandmaincauseofinfertilityinwomenundergoingassistedreproductivetreatmentretrospectiveobservationalcohortstudy AT wangliying predictingectopicpregnancyusinghumanchorionicgonadotropinhcglevelsandmaincauseofinfertilityinwomenundergoingassistedreproductivetreatmentretrospectiveobservationalcohortstudy AT zhanghongxia predictingectopicpregnancyusinghumanchorionicgonadotropinhcglevelsandmaincauseofinfertilityinwomenundergoingassistedreproductivetreatmentretrospectiveobservationalcohortstudy AT lirong predictingectopicpregnancyusinghumanchorionicgonadotropinhcglevelsandmaincauseofinfertilityinwomenundergoingassistedreproductivetreatmentretrospectiveobservationalcohortstudy AT qiaojie predictingectopicpregnancyusinghumanchorionicgonadotropinhcglevelsandmaincauseofinfertilityinwomenundergoingassistedreproductivetreatmentretrospectiveobservationalcohortstudy |