Cargando…
The role of transporters in cancer redox homeostasis and cross-talk with nanomedicines
Tumor cell usually exhibits high levels of reactive oxygen species and adaptive antioxidant system due to the metabolic, genetic, and microenvironment-associated alterations. The altered redox homeostasis can promote tumor progression, development, and treatment resistance. Several membrane transpor...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shenyang Pharmaceutical University
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193452/ https://www.ncbi.nlm.nih.gov/pubmed/32373196 http://dx.doi.org/10.1016/j.ajps.2020.02.001 |
_version_ | 1783528201357623296 |
---|---|
author | Kou, Longfa Jiang, Xinyu Huang, Huirong Lin, Xinlu Zhang, Youting Yao, Qing Chen, Ruijie |
author_facet | Kou, Longfa Jiang, Xinyu Huang, Huirong Lin, Xinlu Zhang, Youting Yao, Qing Chen, Ruijie |
author_sort | Kou, Longfa |
collection | PubMed |
description | Tumor cell usually exhibits high levels of reactive oxygen species and adaptive antioxidant system due to the metabolic, genetic, and microenvironment-associated alterations. The altered redox homeostasis can promote tumor progression, development, and treatment resistance. Several membrane transporters are involved in the resetting redox homeostasis and play important roles in tumor progression. Therefore, targeting the involved transporters to disrupt the altered redox balance emerges as a viable strategy for cancer therapy. In addition, nanomedicines have drawn much attention in the past decades. Using nanomedicines to target or reset the redox homeostasis alone or combined with other therapies has brought convincing data in cancer treatment. In this review, we will introduce the altered redox balance in cancer metabolism and involved transporters, and highlight the recent advancements of redox-modulating nanomedicines for cancer treatment. |
format | Online Article Text |
id | pubmed-7193452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Shenyang Pharmaceutical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-71934522020-05-05 The role of transporters in cancer redox homeostasis and cross-talk with nanomedicines Kou, Longfa Jiang, Xinyu Huang, Huirong Lin, Xinlu Zhang, Youting Yao, Qing Chen, Ruijie Asian J Pharm Sci Review article Tumor cell usually exhibits high levels of reactive oxygen species and adaptive antioxidant system due to the metabolic, genetic, and microenvironment-associated alterations. The altered redox homeostasis can promote tumor progression, development, and treatment resistance. Several membrane transporters are involved in the resetting redox homeostasis and play important roles in tumor progression. Therefore, targeting the involved transporters to disrupt the altered redox balance emerges as a viable strategy for cancer therapy. In addition, nanomedicines have drawn much attention in the past decades. Using nanomedicines to target or reset the redox homeostasis alone or combined with other therapies has brought convincing data in cancer treatment. In this review, we will introduce the altered redox balance in cancer metabolism and involved transporters, and highlight the recent advancements of redox-modulating nanomedicines for cancer treatment. Shenyang Pharmaceutical University 2020-03 2020-03-03 /pmc/articles/PMC7193452/ /pubmed/32373196 http://dx.doi.org/10.1016/j.ajps.2020.02.001 Text en © 2020 Shenyang Pharmaceutical University. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review article Kou, Longfa Jiang, Xinyu Huang, Huirong Lin, Xinlu Zhang, Youting Yao, Qing Chen, Ruijie The role of transporters in cancer redox homeostasis and cross-talk with nanomedicines |
title | The role of transporters in cancer redox homeostasis and cross-talk with nanomedicines |
title_full | The role of transporters in cancer redox homeostasis and cross-talk with nanomedicines |
title_fullStr | The role of transporters in cancer redox homeostasis and cross-talk with nanomedicines |
title_full_unstemmed | The role of transporters in cancer redox homeostasis and cross-talk with nanomedicines |
title_short | The role of transporters in cancer redox homeostasis and cross-talk with nanomedicines |
title_sort | role of transporters in cancer redox homeostasis and cross-talk with nanomedicines |
topic | Review article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193452/ https://www.ncbi.nlm.nih.gov/pubmed/32373196 http://dx.doi.org/10.1016/j.ajps.2020.02.001 |
work_keys_str_mv | AT koulongfa theroleoftransportersincancerredoxhomeostasisandcrosstalkwithnanomedicines AT jiangxinyu theroleoftransportersincancerredoxhomeostasisandcrosstalkwithnanomedicines AT huanghuirong theroleoftransportersincancerredoxhomeostasisandcrosstalkwithnanomedicines AT linxinlu theroleoftransportersincancerredoxhomeostasisandcrosstalkwithnanomedicines AT zhangyouting theroleoftransportersincancerredoxhomeostasisandcrosstalkwithnanomedicines AT yaoqing theroleoftransportersincancerredoxhomeostasisandcrosstalkwithnanomedicines AT chenruijie theroleoftransportersincancerredoxhomeostasisandcrosstalkwithnanomedicines AT koulongfa roleoftransportersincancerredoxhomeostasisandcrosstalkwithnanomedicines AT jiangxinyu roleoftransportersincancerredoxhomeostasisandcrosstalkwithnanomedicines AT huanghuirong roleoftransportersincancerredoxhomeostasisandcrosstalkwithnanomedicines AT linxinlu roleoftransportersincancerredoxhomeostasisandcrosstalkwithnanomedicines AT zhangyouting roleoftransportersincancerredoxhomeostasisandcrosstalkwithnanomedicines AT yaoqing roleoftransportersincancerredoxhomeostasisandcrosstalkwithnanomedicines AT chenruijie roleoftransportersincancerredoxhomeostasisandcrosstalkwithnanomedicines |