Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer

Based on the evidence that hemochromatosis, an iron-overload disease, drives hepatocellular carcinoma, we hypothesized that chronic exposure to excess iron, either due to genetic or environmental causes, predisposes an individual to cancer. Using pancreatic cancer as our primary focus, we employed c...

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Detalles Bibliográficos
Autores principales: Bhutia, Yangzom D., Ogura, Jiro, Grippo, Paul J., Torres, Carolina, Sato, Toshihiro, Wachtel, Mitchell, Ramachandran, Sabarish, Babu, Ellappan, Sivaprakasam, Sathish, Rajasekaran, Devaraja, Schniers, Bradley, On, Nhu, Smoot, Logan, Thangaraju, Muthusamy, Gnana-Prakasam, Jaya P., Ganapathy, Vadivel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2020
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193456/
https://www.ncbi.nlm.nih.gov/pubmed/32373202
http://dx.doi.org/10.1016/j.ajps.2020.02.003

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