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Combined inhibition of MDM2 and BCR-ABL1 tyrosine kinase targets chronic myeloid leukemia stem/progenitor cells in a murine model

Although highly effective, BCR-ABL1 tyrosine kinase inhibitors do not target chronic myeloid leukemia (CML) stem cells. Most patients relapse upon tyrosine kinase inhibitor therapy cessation. We reported previously that combined BCR-ABL1 and BCL-2 inhibition synergistically targets CML stem/progenit...

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Detalles Bibliográficos
Autores principales:	Carter, Bing Z., Mak, Po Yee, Mu, Hong, Wang, Xiangmeng, Tao, Wenjing, Mak, Duncan H., Dettman, Elisha J., Cardone, Michael, Zernovak, Oleg, Seki, Takahiko, Andreeff, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ferrata Storti Foundation 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193504/ https://www.ncbi.nlm.nih.gov/pubmed/31371419 http://dx.doi.org/10.3324/haematol.2019.219261

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