Bcl-3 promotes Wnt signaling by maintaining the acetylation of β-catenin at lysine 49 in colorectal cancer

Wnt/β-catenin signaling plays a critical role in colorectal cancer (CRC) tumorigenesis and the homeostasis of colorectal cancer stem cells (CSCs), but its molecular mechanism remains unclear. B-cell lymphoma 3 (Bcl-3), a member of the IκB family, is overexpressed in CRC and promotes tumorigenicity....

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Detalles Bibliográficos
Autores principales: Chen, Xi, Wang, Chen, Jiang, Yuhang, Wang, Qi, Tao, Yu, Zhang, Haohao, Zhao, Yongxu, Hu, Yiming, Li, Cuifeng, Ye, Deji, Liu, Dandan, Jiang, Wenxia, Chin, Eugene Y., Chen, Sheng, Liu, Yongzhong, Wang, Mingliang, Liu, Sanhong, Zhang, Xiaoren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193563/
https://www.ncbi.nlm.nih.gov/pubmed/32355204
http://dx.doi.org/10.1038/s41392-020-0138-6

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