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Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair

Repair of double strand DNA breaks (DSBs) can result in gene disruption or gene modification via homology directed repair (HDR) from donor DNA. Altering cellular responses to DSBs may rebalance editing outcomes towards HDR and away from other repair outcomes. Here, we utilize a pooled CRISPR screen...

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Detalles Bibliográficos
Autores principales:	Wienert, Beeke, Nguyen, David N., Guenther, Alexis, Feng, Sharon J., Locke, Melissa N., Wyman, Stacia K., Shin, Jiyung, Kazane, Katelynn R., Gregory, Georgia L., Carter, Matthew A. M., Wright, Francis, Conklin, Bruce R., Marson, Alex, Richardson, Chris D., Corn, Jacob E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193628/ https://www.ncbi.nlm.nih.gov/pubmed/32355159 http://dx.doi.org/10.1038/s41467-020-15845-1

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