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In vivo evidence for extracellular DNA trap formation
Extracellular DNA trap formation is a cellular function of neutrophils, eosinophils, and basophils that facilitates the immobilization and killing of invading microorganisms in the extracellular milieu. To form extracellular traps, granulocytes release a scaffold consisting of mitochondrial DNA in a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193637/ https://www.ncbi.nlm.nih.gov/pubmed/32355207 http://dx.doi.org/10.1038/s41419-020-2497-x |
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author | Yousefi, Shida Simon, Dagmar Stojkov, Darko Karsonova, Antonina Karaulov, Alexander Simon, Hans-Uwe |
author_facet | Yousefi, Shida Simon, Dagmar Stojkov, Darko Karsonova, Antonina Karaulov, Alexander Simon, Hans-Uwe |
author_sort | Yousefi, Shida |
collection | PubMed |
description | Extracellular DNA trap formation is a cellular function of neutrophils, eosinophils, and basophils that facilitates the immobilization and killing of invading microorganisms in the extracellular milieu. To form extracellular traps, granulocytes release a scaffold consisting of mitochondrial DNA in association with granule proteins. As we understand more about the molecular mechanism for the formation of extracellular DNA traps, the in vivo function of this phenomenon under pathological conditions remains an enigma. In this article, we critically review the literature to summarize the evidence for extracellular DNA trap formation under in vivo conditions. Extracellular DNA traps have not only been detected in infectious diseases but also in chronic inflammatory diseases, as well as in cancer. While on the one hand, extracellular DNA traps clearly exhibit an important function in host defense, it appears that they can also contribute to the maintenance of inflammation and metastasis, suggesting that they may represent an interesting drug target for such pathological conditions. |
format | Online Article Text |
id | pubmed-7193637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-71936372020-05-04 In vivo evidence for extracellular DNA trap formation Yousefi, Shida Simon, Dagmar Stojkov, Darko Karsonova, Antonina Karaulov, Alexander Simon, Hans-Uwe Cell Death Dis Review Article Extracellular DNA trap formation is a cellular function of neutrophils, eosinophils, and basophils that facilitates the immobilization and killing of invading microorganisms in the extracellular milieu. To form extracellular traps, granulocytes release a scaffold consisting of mitochondrial DNA in association with granule proteins. As we understand more about the molecular mechanism for the formation of extracellular DNA traps, the in vivo function of this phenomenon under pathological conditions remains an enigma. In this article, we critically review the literature to summarize the evidence for extracellular DNA trap formation under in vivo conditions. Extracellular DNA traps have not only been detected in infectious diseases but also in chronic inflammatory diseases, as well as in cancer. While on the one hand, extracellular DNA traps clearly exhibit an important function in host defense, it appears that they can also contribute to the maintenance of inflammation and metastasis, suggesting that they may represent an interesting drug target for such pathological conditions. Nature Publishing Group UK 2020-04-30 /pmc/articles/PMC7193637/ /pubmed/32355207 http://dx.doi.org/10.1038/s41419-020-2497-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article Yousefi, Shida Simon, Dagmar Stojkov, Darko Karsonova, Antonina Karaulov, Alexander Simon, Hans-Uwe In vivo evidence for extracellular DNA trap formation |
title | In vivo evidence for extracellular DNA trap formation |
title_full | In vivo evidence for extracellular DNA trap formation |
title_fullStr | In vivo evidence for extracellular DNA trap formation |
title_full_unstemmed | In vivo evidence for extracellular DNA trap formation |
title_short | In vivo evidence for extracellular DNA trap formation |
title_sort | in vivo evidence for extracellular dna trap formation |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193637/ https://www.ncbi.nlm.nih.gov/pubmed/32355207 http://dx.doi.org/10.1038/s41419-020-2497-x |
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