Cargando…
Investigating hormone-induced changes in affective state using the affective bias test in male and female rats
Recent clinical and pre-clinical research suggests that affective biases may play an important role in the development and perpetuation of mood disorders. Studies in animals have also revealed that similar neuropsychological processes can be measured in non-human species using behavioural assays des...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Pergamon Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193894/ https://www.ncbi.nlm.nih.gov/pubmed/32179367 http://dx.doi.org/10.1016/j.psyneuen.2020.104647 |
_version_ | 1783528270850949120 |
---|---|
author | Hinchcliffe, Justyna K. Mendl, Michael Robinson, Emma S.J. |
author_facet | Hinchcliffe, Justyna K. Mendl, Michael Robinson, Emma S.J. |
author_sort | Hinchcliffe, Justyna K. |
collection | PubMed |
description | Recent clinical and pre-clinical research suggests that affective biases may play an important role in the development and perpetuation of mood disorders. Studies in animals have also revealed that similar neuropsychological processes can be measured in non-human species using behavioural assays designed to measure biases in learning and memory or decision-making. Given the proposed links between hormones and mood, we used the affective bias test to investigate the effects of different hormone treatments in both male and female rats. Animals were pre-treated with acute doses of hormone or vehicle control prior to learning each of two independent substrate-reward associations. During a subsequent choice test, positive or negative biases were observed by animal’s preference towards or away from the substrate learnt during drug treatment respectively. In both sexes, oestradiol and the oestrogen-like compound bisphenol A induced positive biases, whilst blockade of oestrogen hormones with formestane induced a negative bias. Progesterone induced a negative bias in both sexes, but testosterone only induced a negative bias in males. Blocking testosterone with flutamide induced a positive bias in both sexes at the higher dose (10 mg/kg). The oxytocin analogue, carbetocin induced positive biases in both sexes but the vasopressin analogue, desmopressin, induced a positive bias in male rats only. These results provide evidence that modulating levels of hormones using exogenous treatments can induce affective biases in rats. They also suggest that hormone-induced affective biases influence cognitive and emotional behaviour and could have longer-term effects in some mood disorders. |
format | Online Article Text |
id | pubmed-7193894 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Pergamon Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-71938942020-05-05 Investigating hormone-induced changes in affective state using the affective bias test in male and female rats Hinchcliffe, Justyna K. Mendl, Michael Robinson, Emma S.J. Psychoneuroendocrinology Article Recent clinical and pre-clinical research suggests that affective biases may play an important role in the development and perpetuation of mood disorders. Studies in animals have also revealed that similar neuropsychological processes can be measured in non-human species using behavioural assays designed to measure biases in learning and memory or decision-making. Given the proposed links between hormones and mood, we used the affective bias test to investigate the effects of different hormone treatments in both male and female rats. Animals were pre-treated with acute doses of hormone or vehicle control prior to learning each of two independent substrate-reward associations. During a subsequent choice test, positive or negative biases were observed by animal’s preference towards or away from the substrate learnt during drug treatment respectively. In both sexes, oestradiol and the oestrogen-like compound bisphenol A induced positive biases, whilst blockade of oestrogen hormones with formestane induced a negative bias. Progesterone induced a negative bias in both sexes, but testosterone only induced a negative bias in males. Blocking testosterone with flutamide induced a positive bias in both sexes at the higher dose (10 mg/kg). The oxytocin analogue, carbetocin induced positive biases in both sexes but the vasopressin analogue, desmopressin, induced a positive bias in male rats only. These results provide evidence that modulating levels of hormones using exogenous treatments can induce affective biases in rats. They also suggest that hormone-induced affective biases influence cognitive and emotional behaviour and could have longer-term effects in some mood disorders. Pergamon Press 2020-05 /pmc/articles/PMC7193894/ /pubmed/32179367 http://dx.doi.org/10.1016/j.psyneuen.2020.104647 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hinchcliffe, Justyna K. Mendl, Michael Robinson, Emma S.J. Investigating hormone-induced changes in affective state using the affective bias test in male and female rats |
title | Investigating hormone-induced changes in affective state using the affective bias test in male and female rats |
title_full | Investigating hormone-induced changes in affective state using the affective bias test in male and female rats |
title_fullStr | Investigating hormone-induced changes in affective state using the affective bias test in male and female rats |
title_full_unstemmed | Investigating hormone-induced changes in affective state using the affective bias test in male and female rats |
title_short | Investigating hormone-induced changes in affective state using the affective bias test in male and female rats |
title_sort | investigating hormone-induced changes in affective state using the affective bias test in male and female rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193894/ https://www.ncbi.nlm.nih.gov/pubmed/32179367 http://dx.doi.org/10.1016/j.psyneuen.2020.104647 |
work_keys_str_mv | AT hinchcliffejustynak investigatinghormoneinducedchangesinaffectivestateusingtheaffectivebiastestinmaleandfemalerats AT mendlmichael investigatinghormoneinducedchangesinaffectivestateusingtheaffectivebiastestinmaleandfemalerats AT robinsonemmasj investigatinghormoneinducedchangesinaffectivestateusingtheaffectivebiastestinmaleandfemalerats |