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Oncogenic Ras downregulates mdr1b expression through generation of reactive oxygen species

In the present study, we investigated the effect of oncogenic H-Ras on rat mdr1b expression in NIH3T3 cells. The constitutive expression of H-Ras(V12) was found to downregulate the mdr1b promoter activity and mdr1b mRNA expression. The doxorubicin-induced mdr1b promoter activity of the H-Ras(V12) ex...

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Detalles Bibliográficos
Autores principales:	Jun, Semo, Kim, Seok Won, Kim, Byeol, Chang, In-Youb, Park, Seon-Joo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Physiological Society and The Korean Society of Pharmacology 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193907/ https://www.ncbi.nlm.nih.gov/pubmed/32392918 http://dx.doi.org/10.4196/kjpp.2020.24.3.267

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