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Immediate impact of COVID-19 on transplant activity in the Netherlands

The rapid emergence of the COVID-19 pandemic is unprecedented and poses an unparalleled obstacle in the sixty-five year history of organ transplantation. Worldwide, the delivery of transplant care is severely challenged by matters concerning - but not limited to - organ procurement, risk of SARS-CoV...

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Autores principales: de Vries, A.P.J., Alwayn, I.P.J., Hoek, R.A.S., van den Berg, A.P., Ultee, F.C.W., Vogelaar, S.M., Haase-Kromwijk, B.J.J.M., Heemskerk, M.B.A., Hemke, A.C., Nijboer, W.N., Schaefer, B.S., Kuiper, M.A., de Jonge, J., van der Kaaij, N.P., Reinders, M.E.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194049/
https://www.ncbi.nlm.nih.gov/pubmed/32371150
http://dx.doi.org/10.1016/j.trim.2020.101304
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author de Vries, A.P.J.
Alwayn, I.P.J.
Hoek, R.A.S.
van den Berg, A.P.
Ultee, F.C.W.
Vogelaar, S.M.
Haase-Kromwijk, B.J.J.M.
Heemskerk, M.B.A.
Hemke, A.C.
Nijboer, W.N.
Schaefer, B.S.
Kuiper, M.A.
de Jonge, J.
van der Kaaij, N.P.
Reinders, M.E.J.
author_facet de Vries, A.P.J.
Alwayn, I.P.J.
Hoek, R.A.S.
van den Berg, A.P.
Ultee, F.C.W.
Vogelaar, S.M.
Haase-Kromwijk, B.J.J.M.
Heemskerk, M.B.A.
Hemke, A.C.
Nijboer, W.N.
Schaefer, B.S.
Kuiper, M.A.
de Jonge, J.
van der Kaaij, N.P.
Reinders, M.E.J.
author_sort de Vries, A.P.J.
collection PubMed
description The rapid emergence of the COVID-19 pandemic is unprecedented and poses an unparalleled obstacle in the sixty-five year history of organ transplantation. Worldwide, the delivery of transplant care is severely challenged by matters concerning - but not limited to - organ procurement, risk of SARS-CoV-2 transmission, screening strategies of donors and recipients, decisions to postpone or proceed with transplantation, the attributable risk of immunosuppression for COVID-19 and entrenched health care resources and capacity. The transplant community is faced with choosing a lesser of two evils: initiating immunosuppression and potentially accepting detrimental outcome when transplant recipients develop COVID-19 versus postponing transplantation and accepting associated waitlist mortality. Notably, prioritization of health care services for COVID-19 care raises concerns about allocation of resources to deliver care for transplant patients who might otherwise have excellent 1-year and 10-year survival rates. Children and young adults with end-stage organ disease in particular seem more disadvantaged by withholding transplantation because of capacity issues than from medical consequences of SARS-CoV-2. This report details the nationwide response of the Dutch transplant community to these issues and the immediate consequences for transplant activity. Worrisome, there was a significant decrease in organ donation numbers affecting all organ transplant services. In addition, there was a detrimental effect on transplantation numbers in children with end-organ failure. Ongoing efforts focus on mitigation of not only primary but also secondary harm of the pandemic and to find right definitions and momentum to restore the transplant programs.
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spelling pubmed-71940492020-05-02 Immediate impact of COVID-19 on transplant activity in the Netherlands de Vries, A.P.J. Alwayn, I.P.J. Hoek, R.A.S. van den Berg, A.P. Ultee, F.C.W. Vogelaar, S.M. Haase-Kromwijk, B.J.J.M. Heemskerk, M.B.A. Hemke, A.C. Nijboer, W.N. Schaefer, B.S. Kuiper, M.A. de Jonge, J. van der Kaaij, N.P. Reinders, M.E.J. Transpl Immunol Article The rapid emergence of the COVID-19 pandemic is unprecedented and poses an unparalleled obstacle in the sixty-five year history of organ transplantation. Worldwide, the delivery of transplant care is severely challenged by matters concerning - but not limited to - organ procurement, risk of SARS-CoV-2 transmission, screening strategies of donors and recipients, decisions to postpone or proceed with transplantation, the attributable risk of immunosuppression for COVID-19 and entrenched health care resources and capacity. The transplant community is faced with choosing a lesser of two evils: initiating immunosuppression and potentially accepting detrimental outcome when transplant recipients develop COVID-19 versus postponing transplantation and accepting associated waitlist mortality. Notably, prioritization of health care services for COVID-19 care raises concerns about allocation of resources to deliver care for transplant patients who might otherwise have excellent 1-year and 10-year survival rates. Children and young adults with end-stage organ disease in particular seem more disadvantaged by withholding transplantation because of capacity issues than from medical consequences of SARS-CoV-2. This report details the nationwide response of the Dutch transplant community to these issues and the immediate consequences for transplant activity. Worrisome, there was a significant decrease in organ donation numbers affecting all organ transplant services. In addition, there was a detrimental effect on transplantation numbers in children with end-organ failure. Ongoing efforts focus on mitigation of not only primary but also secondary harm of the pandemic and to find right definitions and momentum to restore the transplant programs. Elsevier B.V. 2020-08 2020-05-01 /pmc/articles/PMC7194049/ /pubmed/32371150 http://dx.doi.org/10.1016/j.trim.2020.101304 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
de Vries, A.P.J.
Alwayn, I.P.J.
Hoek, R.A.S.
van den Berg, A.P.
Ultee, F.C.W.
Vogelaar, S.M.
Haase-Kromwijk, B.J.J.M.
Heemskerk, M.B.A.
Hemke, A.C.
Nijboer, W.N.
Schaefer, B.S.
Kuiper, M.A.
de Jonge, J.
van der Kaaij, N.P.
Reinders, M.E.J.
Immediate impact of COVID-19 on transplant activity in the Netherlands
title Immediate impact of COVID-19 on transplant activity in the Netherlands
title_full Immediate impact of COVID-19 on transplant activity in the Netherlands
title_fullStr Immediate impact of COVID-19 on transplant activity in the Netherlands
title_full_unstemmed Immediate impact of COVID-19 on transplant activity in the Netherlands
title_short Immediate impact of COVID-19 on transplant activity in the Netherlands
title_sort immediate impact of covid-19 on transplant activity in the netherlands
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194049/
https://www.ncbi.nlm.nih.gov/pubmed/32371150
http://dx.doi.org/10.1016/j.trim.2020.101304
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