A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

The pandemic coronavirus SARS-CoV-2 threatens public health worldwide. The viral spike protein mediates SARS-CoV-2 entry into host cells and harbors a S1/S2 cleavage site containing multiple arginine residues (multibasic) not found in closely related animal coronaviruses. However, the role of this m...

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Detalles Bibliográficos
Autores principales: Hoffmann, Markus, Kleine-Weber, Hannah, Pöhlmann, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194065/
https://www.ncbi.nlm.nih.gov/pubmed/32362314
http://dx.doi.org/10.1016/j.molcel.2020.04.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194065/
https://www.ncbi.nlm.nih.gov/pubmed/32362314
http://dx.doi.org/10.1016/j.molcel.2020.04.022

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