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Rational design of peptides for identification of linear epitopes and generation of neutralizing monoclonal antibodies against DKK2 for cancer therapy

Dickkopf-related protein 2 (DKK2)is a member of the Dickkopf family in Wnt signaling pathway. Recently, we found that antibodies against DKK2 could activate natural killer (NK) and CD8+ T cells in tumors and inhibit tumor growth. In this paper, we report the rational design of peptides for identific...

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Detalles Bibliográficos
Autores principales:	Zhao, Rongqing, Xiao, Qian, Li, Maohua, Ren, Wenlin, Xia, Chenxi, Liu, Xudong, Li, Yingzi, Tan, Tan, Wu, Dianqing, Sun, Le
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194219/ https://www.ncbi.nlm.nih.gov/pubmed/32391516 http://dx.doi.org/10.1093/abt/tbaa004

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