Goshajinkigan, a Traditional Japanese Medicine, Suppresses Voltage-Gated Sodium Channel Nav1.4 Currents in C2C12 Cells

Goshajinkigan (GJG) is a traditional Japanese Kampo medicine used clinically to treat muscle pain in Japan. However, its underlying mechanism remains unclear. Since voltage-gated sodium channel (Nav) 1.4 is involved in skeletal muscle contraction, we investigated the possibility that GJG may affect...

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Autores principales: Imai, Ryota, Horita, Shoichiro, Ono, Yuko, Hagihara, Keisuke, Shimizu, Masaru, Maejima, Yuko, Shimomura, Kenju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194311/
https://www.ncbi.nlm.nih.gov/pubmed/32368413
http://dx.doi.org/10.1089/biores.2019.0034
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author Imai, Ryota
Horita, Shoichiro
Ono, Yuko
Hagihara, Keisuke
Shimizu, Masaru
Maejima, Yuko
Shimomura, Kenju
author_facet Imai, Ryota
Horita, Shoichiro
Ono, Yuko
Hagihara, Keisuke
Shimizu, Masaru
Maejima, Yuko
Shimomura, Kenju
author_sort Imai, Ryota
collection PubMed
description Goshajinkigan (GJG) is a traditional Japanese Kampo medicine used clinically to treat muscle pain in Japan. However, its underlying mechanism remains unclear. Since voltage-gated sodium channel (Nav) 1.4 is involved in skeletal muscle contraction, we investigated the possibility that GJG may affect Nav1.4 currents. By using an electrophysiological technique on skeletal muscle cell line C2C12, we found that GJG suppresses Nav1.4 currents in C2C12 cells. It is suggested that GJG may improve skeletal muscle stiffness or cramps by inhibiting abnormal Nav1.4 excitation. GJG may act as a Nav1.4 blocker and may be useful to treat muscle stiffness and clamps as well as easing the pain.
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spelling pubmed-71943112020-05-04 Goshajinkigan, a Traditional Japanese Medicine, Suppresses Voltage-Gated Sodium Channel Nav1.4 Currents in C2C12 Cells Imai, Ryota Horita, Shoichiro Ono, Yuko Hagihara, Keisuke Shimizu, Masaru Maejima, Yuko Shimomura, Kenju Biores Open Access Brief Report Goshajinkigan (GJG) is a traditional Japanese Kampo medicine used clinically to treat muscle pain in Japan. However, its underlying mechanism remains unclear. Since voltage-gated sodium channel (Nav) 1.4 is involved in skeletal muscle contraction, we investigated the possibility that GJG may affect Nav1.4 currents. By using an electrophysiological technique on skeletal muscle cell line C2C12, we found that GJG suppresses Nav1.4 currents in C2C12 cells. It is suggested that GJG may improve skeletal muscle stiffness or cramps by inhibiting abnormal Nav1.4 excitation. GJG may act as a Nav1.4 blocker and may be useful to treat muscle stiffness and clamps as well as easing the pain. Mary Ann Liebert, Inc., publishers 2020-04-27 /pmc/articles/PMC7194311/ /pubmed/32368413 http://dx.doi.org/10.1089/biores.2019.0034 Text en © Ryota Imai et al. 2020; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Imai, Ryota
Horita, Shoichiro
Ono, Yuko
Hagihara, Keisuke
Shimizu, Masaru
Maejima, Yuko
Shimomura, Kenju
Goshajinkigan, a Traditional Japanese Medicine, Suppresses Voltage-Gated Sodium Channel Nav1.4 Currents in C2C12 Cells
title Goshajinkigan, a Traditional Japanese Medicine, Suppresses Voltage-Gated Sodium Channel Nav1.4 Currents in C2C12 Cells
title_full Goshajinkigan, a Traditional Japanese Medicine, Suppresses Voltage-Gated Sodium Channel Nav1.4 Currents in C2C12 Cells
title_fullStr Goshajinkigan, a Traditional Japanese Medicine, Suppresses Voltage-Gated Sodium Channel Nav1.4 Currents in C2C12 Cells
title_full_unstemmed Goshajinkigan, a Traditional Japanese Medicine, Suppresses Voltage-Gated Sodium Channel Nav1.4 Currents in C2C12 Cells
title_short Goshajinkigan, a Traditional Japanese Medicine, Suppresses Voltage-Gated Sodium Channel Nav1.4 Currents in C2C12 Cells
title_sort goshajinkigan, a traditional japanese medicine, suppresses voltage-gated sodium channel nav1.4 currents in c2c12 cells
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194311/
https://www.ncbi.nlm.nih.gov/pubmed/32368413
http://dx.doi.org/10.1089/biores.2019.0034
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