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Clinical parameters and biomarkers predicting spontaneous operational tolerance after liver transplantation: a scoping review protocol

Objective: This scoping review aims at systematically mapping reported prognostic factors for spontaneous immunosuppression (IS) free allograft tolerance (operational tolerance, OT) in non-viral hepatitis and non-autoimmune disease liver transplant (LT) recipients who are undergoing immunosuppressio...

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Autores principales: Appenzeller-Herzog, Christian, Hartleif, Steffen, Vionnet, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194345/
https://www.ncbi.nlm.nih.gov/pubmed/32399186
http://dx.doi.org/10.12688/f1000research.21501.3
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author Appenzeller-Herzog, Christian
Hartleif, Steffen
Vionnet, Julien
author_facet Appenzeller-Herzog, Christian
Hartleif, Steffen
Vionnet, Julien
author_sort Appenzeller-Herzog, Christian
collection PubMed
description Objective: This scoping review aims at systematically mapping reported prognostic factors for spontaneous immunosuppression (IS) free allograft tolerance (operational tolerance, OT) in non-viral hepatitis and non-autoimmune disease liver transplant (LT) recipients who are undergoing immunosuppression withdrawal (ISW). The results may inform the subsequent conduct of a systematic review with a more specific review question. Background: LT is currently the most effective treatment for end-stage liver diseases. Whereas the short-term outcomes after LT have dramatically improved over the last decades, the long-term outcomes remain unsatisfactory, mainly because of side effects of lifelong IS, such as infections, cardiovascular diseases, malignancies, and nephrotoxicity. ISW studies have shown that OT can be achieved by a subset of LT recipients and recent research has identified biomarkers of OT in these patients. However, an evidence-based selection algorithm for patients that can predictably benefit from ISW is not available to date. The planned review will, therefore, map existing knowledge on prognostic clinical parameters and biomarkers for OT. Inclusion criteria: We will consider studies that record any clinical parameter or biomarker before the initiation of ISW in paediatric or adult non-viral hepatitis and non-autoimmune disease LT recipients and analyse their possible association with ISW outcomes (OT or non-tolerance). Studies addressing the effectiveness of OT-inducing treatments will be excluded. Methods: Embase, MEDLINE, and Cochrane Library will be searched for relevant articles or conference abstracts. Full-texts of selected abstracts will be independently screened for inclusion by two reviewers. References and citing articles of included records will be screened for additional relevant records. Clinical trial registries will be searched for ongoing studies, and their investigators contacted for the sharing of unpublished data. Data from included records will be independently extracted by two reviewers using a prespecified data extraction table and presented in both tabular and narrative form.
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spelling pubmed-71943452020-05-11 Clinical parameters and biomarkers predicting spontaneous operational tolerance after liver transplantation: a scoping review protocol Appenzeller-Herzog, Christian Hartleif, Steffen Vionnet, Julien F1000Res Study Protocol Objective: This scoping review aims at systematically mapping reported prognostic factors for spontaneous immunosuppression (IS) free allograft tolerance (operational tolerance, OT) in non-viral hepatitis and non-autoimmune disease liver transplant (LT) recipients who are undergoing immunosuppression withdrawal (ISW). The results may inform the subsequent conduct of a systematic review with a more specific review question. Background: LT is currently the most effective treatment for end-stage liver diseases. Whereas the short-term outcomes after LT have dramatically improved over the last decades, the long-term outcomes remain unsatisfactory, mainly because of side effects of lifelong IS, such as infections, cardiovascular diseases, malignancies, and nephrotoxicity. ISW studies have shown that OT can be achieved by a subset of LT recipients and recent research has identified biomarkers of OT in these patients. However, an evidence-based selection algorithm for patients that can predictably benefit from ISW is not available to date. The planned review will, therefore, map existing knowledge on prognostic clinical parameters and biomarkers for OT. Inclusion criteria: We will consider studies that record any clinical parameter or biomarker before the initiation of ISW in paediatric or adult non-viral hepatitis and non-autoimmune disease LT recipients and analyse their possible association with ISW outcomes (OT or non-tolerance). Studies addressing the effectiveness of OT-inducing treatments will be excluded. Methods: Embase, MEDLINE, and Cochrane Library will be searched for relevant articles or conference abstracts. Full-texts of selected abstracts will be independently screened for inclusion by two reviewers. References and citing articles of included records will be screened for additional relevant records. Clinical trial registries will be searched for ongoing studies, and their investigators contacted for the sharing of unpublished data. Data from included records will be independently extracted by two reviewers using a prespecified data extraction table and presented in both tabular and narrative form. F1000 Research Limited 2020-06-26 /pmc/articles/PMC7194345/ /pubmed/32399186 http://dx.doi.org/10.12688/f1000research.21501.3 Text en Copyright: © 2020 Appenzeller-Herzog C et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Study Protocol
Appenzeller-Herzog, Christian
Hartleif, Steffen
Vionnet, Julien
Clinical parameters and biomarkers predicting spontaneous operational tolerance after liver transplantation: a scoping review protocol
title Clinical parameters and biomarkers predicting spontaneous operational tolerance after liver transplantation: a scoping review protocol
title_full Clinical parameters and biomarkers predicting spontaneous operational tolerance after liver transplantation: a scoping review protocol
title_fullStr Clinical parameters and biomarkers predicting spontaneous operational tolerance after liver transplantation: a scoping review protocol
title_full_unstemmed Clinical parameters and biomarkers predicting spontaneous operational tolerance after liver transplantation: a scoping review protocol
title_short Clinical parameters and biomarkers predicting spontaneous operational tolerance after liver transplantation: a scoping review protocol
title_sort clinical parameters and biomarkers predicting spontaneous operational tolerance after liver transplantation: a scoping review protocol
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194345/
https://www.ncbi.nlm.nih.gov/pubmed/32399186
http://dx.doi.org/10.12688/f1000research.21501.3
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