Cargando…

TGF-beta and TNF-alpha cooperatively induce mesenchymal transition of lymphatic endothelial cells via activation of Activin signals

Lymphatic systems play important roles in the maintenance of fluid homeostasis and undergo anatomical and physiological changes during inflammation and aging. While lymphatic endothelial cells (LECs) undergo mesenchymal transition in response to transforming growth factor-β (TGF-β), the molecular me...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yoshimatsu, Yasuhiro, Kimuro, Shiori, Pauty, Joris, Takagaki, Kazuki, Nomiyama, Sanae, Inagawa, Akihiko, Maeda, Kentaro, Podyma-Inoue, Katarzyna A., Kajiya, Kentaro, Matsunaga, Yukiko T., Watabe, Tetsuro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194440/ https://www.ncbi.nlm.nih.gov/pubmed/32357159 http://dx.doi.org/10.1371/journal.pone.0232356

Ejemplares similares

TNF‐α enhances TGF‐β‐induced endothelial‐to‐mesenchymal transition via TGF‐β signal augmentation
por: Yoshimatsu, Yasuhiro, et al.
Publicado: (2020)

Vasohibin‐2 is required for epithelial–mesenchymal transition of ovarian cancer cells by modulating transforming growth factor‐β signaling
por: Norita, Rie, et al.
Publicado: (2017)

Fibroblast growth factor signals regulate transforming growth factor‐β‐induced endothelial‐to‐myofibroblast transition of tumor endothelial cells via Elk1
por: Akatsu, Yuichi, et al.
Publicado: (2019)

Apelin Inhibits Diet-Induced Obesity by Enhancing Lymphatic and Blood Vessel Integrity
por: Sawane, Mika, et al.
Publicado: (2013)

Expression of platelet-derived growth factor receptor β is maintained by Prox1 in lymphatic endothelial cells and is required for tumor lymphangiogenesis
por: Miyazaki, Hideki, et al.
Publicado: (2014)

VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
por: Hirakawa, Satoshi, et al.
Publicado: (2005)

TGF-β signaling in lymphatic vascular vessel formation and maintenance
por: Itoh, Fumiko, et al.
Publicado: (2022)

A Vascular Permeability Assay Using an In Vitro Human Microvessel Model Mimicking the Inflammatory Condition
por: Pauty, Joris, et al.
Publicado: (2017)

Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition
por: Kobayashi, Miho, et al.
Publicado: (2022)

Roles of TGF-β Signals in Endothelial-Mesenchymal Transition during Cardiac Fibrosis
por: Yoshimatsu, Yasuhiro, et al.
Publicado: (2011)

Emerging roles of inflammation-mediated endothelial–mesenchymal transition in health and disease
por: Yoshimatsu, Yasuhiro, et al.
Publicado: (2022)

Activation of β2‐adrenergic receptor signals suppresses mesenchymal phenotypes of oral squamous cell carcinoma cells
por: Sakakitani, Shintaro, et al.
Publicado: (2020)

Isolation and characterisation of lymphatic endothelial cells from lung tissues affected by lymphangioleiomyomatosis
por: Nishino, Koichi, et al.
Publicado: (2021)

Lymphatic System Transfer for Lymphedema Treatment: Transferring the Lymph Nodes with Their Lymphatic Vessels
por: Yoshimatsu, Hidehiko, et al.
Publicado: (2020)

Dual targeting of vascular endothelial growth factor and bone morphogenetic protein‐9/10 impairs tumor growth through inhibition of angiogenesis
por: Akatsu, Yuichi, et al.
Publicado: (2017)

Peptide‐2 from mouse myostatin precursor protein alleviates muscle wasting in cancer‐associated cachexia
por: Ojima, Chiharu, et al.
Publicado: (2020)

Immunohistochemical localization of inhibin/activin subunits in adult Asian elephant (Elephas maximus) testes
por: CHAICHANATHONG, Sirinart, et al.
Publicado: (2018)

Expression of lymphatic markers and lymphatic growth factors in psoriasis before and after anti-TNF treatment
por: Moustou, Aikaterini Evangelia, et al.
Publicado: (2014)

Analytical ultracentrifugation with fluorescence detection system reveals differences in complex formation between recombinant human TNF and different biological TNF antagonists in various environments
por: Krayukhina, Elena, et al.
Publicado: (2017)

A Vascular Endothelial Growth Factor-Dependent Sprouting Angiogenesis Assay Based on an In Vitro Human Blood Vessel Model for the Study of Anti-Angiogenic Drugs
por: Pauty, Joris, et al.
Publicado: (2017)

Progression of melanoma is suppressed by targeting all transforming growth factor-β isoforms with an Fc chimeric receptor
por: Kodama, Shingo, et al.
Publicado: (2021)

Three-dimensional reconstruction of vascular arrangement including the hepatic artery and left gastric vein during gastric surgery
por: Miyamoto, Ryoichi, et al.
Publicado: (2016)

Human eosinophil activin A synthesis and mRNA stabilization are induced by the combination of IL-3 plus TNF
por: Kelly, Elizabeth A., et al.
Publicado: (2016)

Activin eases asthma
por: Leslie, Mitch
Publicado: (2009)

Development of a micronucleus test using the EpiAirway™ organotypic human airway model
por: Munakata, Satoru, et al.
Publicado: (2023)

Interleukin-13 receptor α2 is a novel marker and potential therapeutic target for human melanoma
por: Okamoto, Hayato, et al.
Publicado: (2019)

Abstract: Ultrasound Visualization of the Lymphatic Vessels in the Lower Limbs
por: Hayashi, Akitatsu, et al.
Publicado: (2016)

The orphan ligand, activin C, signals through activin receptor-like kinase 7
por: Goebel, Erich J, et al.
Publicado: (2022)

Circulating activin A during equine gestation and immunolocalization of its receptors system in utero-placental tissues and fetal gonads
por: DHAKAL, Pramod, et al.
Publicado: (2021)

Human and mouse activin genes: Divergent expression of activin A protein variants and identification of a novel heparan sulfate-binding domain in activin B
por: Billings, Paul C., et al.
Publicado: (2020)

Persistent popliteal lymphatic muscle cell coverage defects despite amelioration of arthritis and recovery of popliteal lymphatic vessel function in TNF-Tg mice following anti-TNF therapy
por: Kenney, H. Mark, et al.
Publicado: (2022)

Xnrs and Activin Regulate Distinct Genes during Xenopus Development: Activin Regulates Cell Division
por: Ramis, Joana M., et al.
Publicado: (2007)

An autocrine ActivinB mechanism drives TGFβ/Activin signaling in Group 3 medulloblastoma
por: Morabito, Morgane, et al.
Publicado: (2019)

Activin B and Activin C Have Opposing Effects on Prostate Cancer Progression and Cell Growth
por: Reader, Karen L., et al.
Publicado: (2022)

Antagonistic effects of activin A and TNF-α on the activation of L929 fibroblast cells via Smad3-independent signaling
por: Jiang, Lingling, et al.
Publicado: (2020)

Kinetochore stretching inactivates the spindle assembly checkpoint
por: Uchida, Kazuhiko S.K., et al.
Publicado: (2009)

Variations in activin receptor, inhibin/activin subunit and follistatin mRNAs in human prostate tumour tissues
por: Schaik, R H N van, et al.
Publicado: (2000)

Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects
Publicado: (1995)

Activin A: a novel urinary biomarker of renal impairment in multiple myeloma
por: Iriuchishima, Hirono, et al.
Publicado: (2019)

Targeting activin receptor–like kinase 7 ameliorates adiposity and associated metabolic disorders
por: Zhao, Min, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_neisc2e512gl5mfjo0buoq42h6