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New developments in chondrocyte ER stress and related diseases

Cartilage comprises a single cell type, the chondrocyte, embedded in a highly complex extracellular matrix. Disruption to the cartilage growth plate leads to reduced bone growth and results in a clinically diverse group of conditions known as genetic skeletal diseases (GSDs). Similarly, long-term de...

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Autores principales: Briggs, Michael D., Dennis, Ella P., Dietmar, Helen F., Pirog, Katarzyna A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194456/
https://www.ncbi.nlm.nih.gov/pubmed/32399188
http://dx.doi.org/10.12688/f1000research.22275.1
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author Briggs, Michael D.
Dennis, Ella P.
Dietmar, Helen F.
Pirog, Katarzyna A.
author_facet Briggs, Michael D.
Dennis, Ella P.
Dietmar, Helen F.
Pirog, Katarzyna A.
author_sort Briggs, Michael D.
collection PubMed
description Cartilage comprises a single cell type, the chondrocyte, embedded in a highly complex extracellular matrix. Disruption to the cartilage growth plate leads to reduced bone growth and results in a clinically diverse group of conditions known as genetic skeletal diseases (GSDs). Similarly, long-term degradation of articular cartilage can lead to osteoarthritis (OA), a disease characterised by joint pain and stiffness. As professionally secreting cells, chondrocytes are particularly susceptible to endoplasmic reticulum (ER) stress and this has been identified as a core disease mechanism in a group of clinically and pathologically related GSDs. If unresolved, ER stress can lead to chondrocyte cell death. Recent interest has focused on ER stress as a druggable target for GSDs and this has led to the first clinical trial for a GSD by repurposing an antiepileptic drug. Interestingly, ER stress markers have also been associated with OA in multiple cell and animal models and there is increasing interest in it as a possible therapeutic target for treatment. In summary, chondrocyte ER stress has been identified as a core disease mechanism in GSDs and as a contributory factor in OA. Thus, chondrocyte ER stress is a unifying factor for both common and rare cartilage-related diseases and holds promise as a novel therapeutic target.
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spelling pubmed-71944562020-05-11 New developments in chondrocyte ER stress and related diseases Briggs, Michael D. Dennis, Ella P. Dietmar, Helen F. Pirog, Katarzyna A. F1000Res Review Cartilage comprises a single cell type, the chondrocyte, embedded in a highly complex extracellular matrix. Disruption to the cartilage growth plate leads to reduced bone growth and results in a clinically diverse group of conditions known as genetic skeletal diseases (GSDs). Similarly, long-term degradation of articular cartilage can lead to osteoarthritis (OA), a disease characterised by joint pain and stiffness. As professionally secreting cells, chondrocytes are particularly susceptible to endoplasmic reticulum (ER) stress and this has been identified as a core disease mechanism in a group of clinically and pathologically related GSDs. If unresolved, ER stress can lead to chondrocyte cell death. Recent interest has focused on ER stress as a druggable target for GSDs and this has led to the first clinical trial for a GSD by repurposing an antiepileptic drug. Interestingly, ER stress markers have also been associated with OA in multiple cell and animal models and there is increasing interest in it as a possible therapeutic target for treatment. In summary, chondrocyte ER stress has been identified as a core disease mechanism in GSDs and as a contributory factor in OA. Thus, chondrocyte ER stress is a unifying factor for both common and rare cartilage-related diseases and holds promise as a novel therapeutic target. F1000 Research Limited 2020-04-24 /pmc/articles/PMC7194456/ /pubmed/32399188 http://dx.doi.org/10.12688/f1000research.22275.1 Text en Copyright: © 2020 Briggs MD et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Briggs, Michael D.
Dennis, Ella P.
Dietmar, Helen F.
Pirog, Katarzyna A.
New developments in chondrocyte ER stress and related diseases
title New developments in chondrocyte ER stress and related diseases
title_full New developments in chondrocyte ER stress and related diseases
title_fullStr New developments in chondrocyte ER stress and related diseases
title_full_unstemmed New developments in chondrocyte ER stress and related diseases
title_short New developments in chondrocyte ER stress and related diseases
title_sort new developments in chondrocyte er stress and related diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194456/
https://www.ncbi.nlm.nih.gov/pubmed/32399188
http://dx.doi.org/10.12688/f1000research.22275.1
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