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New developments in chondrocyte ER stress and related diseases
Cartilage comprises a single cell type, the chondrocyte, embedded in a highly complex extracellular matrix. Disruption to the cartilage growth plate leads to reduced bone growth and results in a clinically diverse group of conditions known as genetic skeletal diseases (GSDs). Similarly, long-term de...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194456/ https://www.ncbi.nlm.nih.gov/pubmed/32399188 http://dx.doi.org/10.12688/f1000research.22275.1 |
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author | Briggs, Michael D. Dennis, Ella P. Dietmar, Helen F. Pirog, Katarzyna A. |
author_facet | Briggs, Michael D. Dennis, Ella P. Dietmar, Helen F. Pirog, Katarzyna A. |
author_sort | Briggs, Michael D. |
collection | PubMed |
description | Cartilage comprises a single cell type, the chondrocyte, embedded in a highly complex extracellular matrix. Disruption to the cartilage growth plate leads to reduced bone growth and results in a clinically diverse group of conditions known as genetic skeletal diseases (GSDs). Similarly, long-term degradation of articular cartilage can lead to osteoarthritis (OA), a disease characterised by joint pain and stiffness. As professionally secreting cells, chondrocytes are particularly susceptible to endoplasmic reticulum (ER) stress and this has been identified as a core disease mechanism in a group of clinically and pathologically related GSDs. If unresolved, ER stress can lead to chondrocyte cell death. Recent interest has focused on ER stress as a druggable target for GSDs and this has led to the first clinical trial for a GSD by repurposing an antiepileptic drug. Interestingly, ER stress markers have also been associated with OA in multiple cell and animal models and there is increasing interest in it as a possible therapeutic target for treatment. In summary, chondrocyte ER stress has been identified as a core disease mechanism in GSDs and as a contributory factor in OA. Thus, chondrocyte ER stress is a unifying factor for both common and rare cartilage-related diseases and holds promise as a novel therapeutic target. |
format | Online Article Text |
id | pubmed-7194456 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-71944562020-05-11 New developments in chondrocyte ER stress and related diseases Briggs, Michael D. Dennis, Ella P. Dietmar, Helen F. Pirog, Katarzyna A. F1000Res Review Cartilage comprises a single cell type, the chondrocyte, embedded in a highly complex extracellular matrix. Disruption to the cartilage growth plate leads to reduced bone growth and results in a clinically diverse group of conditions known as genetic skeletal diseases (GSDs). Similarly, long-term degradation of articular cartilage can lead to osteoarthritis (OA), a disease characterised by joint pain and stiffness. As professionally secreting cells, chondrocytes are particularly susceptible to endoplasmic reticulum (ER) stress and this has been identified as a core disease mechanism in a group of clinically and pathologically related GSDs. If unresolved, ER stress can lead to chondrocyte cell death. Recent interest has focused on ER stress as a druggable target for GSDs and this has led to the first clinical trial for a GSD by repurposing an antiepileptic drug. Interestingly, ER stress markers have also been associated with OA in multiple cell and animal models and there is increasing interest in it as a possible therapeutic target for treatment. In summary, chondrocyte ER stress has been identified as a core disease mechanism in GSDs and as a contributory factor in OA. Thus, chondrocyte ER stress is a unifying factor for both common and rare cartilage-related diseases and holds promise as a novel therapeutic target. F1000 Research Limited 2020-04-24 /pmc/articles/PMC7194456/ /pubmed/32399188 http://dx.doi.org/10.12688/f1000research.22275.1 Text en Copyright: © 2020 Briggs MD et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Briggs, Michael D. Dennis, Ella P. Dietmar, Helen F. Pirog, Katarzyna A. New developments in chondrocyte ER stress and related diseases |
title | New developments in chondrocyte ER stress and related diseases |
title_full | New developments in chondrocyte ER stress and related diseases |
title_fullStr | New developments in chondrocyte ER stress and related diseases |
title_full_unstemmed | New developments in chondrocyte ER stress and related diseases |
title_short | New developments in chondrocyte ER stress and related diseases |
title_sort | new developments in chondrocyte er stress and related diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194456/ https://www.ncbi.nlm.nih.gov/pubmed/32399188 http://dx.doi.org/10.12688/f1000research.22275.1 |
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