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A gene-based avian influenza vaccine in poultry

Highly pathogenic avian influenza A (HPAI) viruses, specifically H5N1 strains, cause widespread morbidity and mortality in domestic and wild bird populations, and recent outbreaks have resulted in severe economic losses. Although still largely confined to birds, more than 300 human cases resulting i...

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Detalles Bibliográficos
Autores principales: Rao, S.S., Styles, D., Kong, W., Andrews, C., Gorres, J.P., Nabel, G.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Poultry Science Association Inc. Published by Elsevier Inc. 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194532/
https://www.ncbi.nlm.nih.gov/pubmed/19276436
http://dx.doi.org/10.3382/ps.2008-00360
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author Rao, S.S.
Styles, D.
Kong, W.
Andrews, C.
Gorres, J.P.
Nabel, G.J.
author_facet Rao, S.S.
Styles, D.
Kong, W.
Andrews, C.
Gorres, J.P.
Nabel, G.J.
author_sort Rao, S.S.
collection PubMed
description Highly pathogenic avian influenza A (HPAI) viruses, specifically H5N1 strains, cause widespread morbidity and mortality in domestic and wild bird populations, and recent outbreaks have resulted in severe economic losses. Although still largely confined to birds, more than 300 human cases resulting in deaths have been reported to the World Health Organization. These sporadic human cases result from direct transmission from infected birds; however, a sustained outbreak of HPAI H5N1 increases the potential for the emergence of a human pandemic strain. One approach to the containment of HPAI H5N1 is the development of vaccines for use in poultry. Currently, the majority of avian influenza vaccines for poultry are traditional whole-virus vaccines produced in eggs. Although highly efficacious, these vaccines are hindered by long production times, inflexibility in quickly altering antigenic composition, and limited breadth of protection. Newer vaccines with more efficient manufacturing processes, enhanced efficacy, and cross-protection against multiple strains would improve preparedness. Reverse genetics technology has provided one such method, and emerging gene-based vaccines offer another approach that reduces dependence on egg-based production and human exposure to pathogenic viruses. Gene-based vaccines also provide rapid manufacturing, enhanced precision and versatility, and the capacity to protect against a broad range of viral subtypes. Vectors for these vaccines include replication-defective viruses, bacterial vectors, and DNA. Here we review the features of gene-based vaccination that may facilitate the control of HPAI H5N1 in poultry, and highlight the development of a hemagglutinin-based multivalent DNA vaccine that confers protection in mice and chickens.
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spelling pubmed-71945322020-05-02 A gene-based avian influenza vaccine in poultry Rao, S.S. Styles, D. Kong, W. Andrews, C. Gorres, J.P. Nabel, G.J. Poult Sci Article Highly pathogenic avian influenza A (HPAI) viruses, specifically H5N1 strains, cause widespread morbidity and mortality in domestic and wild bird populations, and recent outbreaks have resulted in severe economic losses. Although still largely confined to birds, more than 300 human cases resulting in deaths have been reported to the World Health Organization. These sporadic human cases result from direct transmission from infected birds; however, a sustained outbreak of HPAI H5N1 increases the potential for the emergence of a human pandemic strain. One approach to the containment of HPAI H5N1 is the development of vaccines for use in poultry. Currently, the majority of avian influenza vaccines for poultry are traditional whole-virus vaccines produced in eggs. Although highly efficacious, these vaccines are hindered by long production times, inflexibility in quickly altering antigenic composition, and limited breadth of protection. Newer vaccines with more efficient manufacturing processes, enhanced efficacy, and cross-protection against multiple strains would improve preparedness. Reverse genetics technology has provided one such method, and emerging gene-based vaccines offer another approach that reduces dependence on egg-based production and human exposure to pathogenic viruses. Gene-based vaccines also provide rapid manufacturing, enhanced precision and versatility, and the capacity to protect against a broad range of viral subtypes. Vectors for these vaccines include replication-defective viruses, bacterial vectors, and DNA. Here we review the features of gene-based vaccination that may facilitate the control of HPAI H5N1 in poultry, and highlight the development of a hemagglutinin-based multivalent DNA vaccine that confers protection in mice and chickens. Poultry Science Association Inc. Published by Elsevier Inc. 2009-04-01 2019-12-11 /pmc/articles/PMC7194532/ /pubmed/19276436 http://dx.doi.org/10.3382/ps.2008-00360 Text en © 2009 Poultry Science Association Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Rao, S.S.
Styles, D.
Kong, W.
Andrews, C.
Gorres, J.P.
Nabel, G.J.
A gene-based avian influenza vaccine in poultry
title A gene-based avian influenza vaccine in poultry
title_full A gene-based avian influenza vaccine in poultry
title_fullStr A gene-based avian influenza vaccine in poultry
title_full_unstemmed A gene-based avian influenza vaccine in poultry
title_short A gene-based avian influenza vaccine in poultry
title_sort gene-based avian influenza vaccine in poultry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194532/
https://www.ncbi.nlm.nih.gov/pubmed/19276436
http://dx.doi.org/10.3382/ps.2008-00360
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