The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design

OBJECTIVE: Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19...

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Detalles Bibliográficos
Autores principales: Deftereos, Spyridon G., Siasos, Gerasimos, Giannopoulos, Georgios, Vrachatis, Dimitrios A., Angelidis, Christos, Giotaki, Sotiria G., Gargalianos, Panagiotis, Giamarellou, Helen, Gogos, Charalampos, Daikos, Georgios, Lazanas, Marios, Lagiou, Pagona, Saroglou, Georgios, Sipsas, Nikolaos, Tsiodras, Sotirios, Chatzigeorgiou, Dimitrios, Moussas, Nikolaos, Kotanidou, Anastasia, Koulouris, Nikolaos, Oikonomou, Evangelos, Kaoukis, Andreas, Kossyvakis, Charalampos, Raisakis, Konstantinos, Fountoulaki, Katerina, Comis, Mihalis, Tsiachris, Dimitrios, Sarri, Eleni, Theodorakis, Andreas, Martinez-Dolz, Luis, Sanz-Sánchez, Jorge, Reimers, Bernhard, Stefanini, Giulio G., Cleman, Michael, Filippou, Dimitrios, Olympios, Christoforos D., Pyrgakis, Vlasios N., Goudevenos, John, Hahalis, George, Kolettis, Theofilos M., Iliodromitis, Efstathios, Tousoulis, Dimitrios, Stefanadis, Christodoulos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hellenic Society of Cardiology. Publishing services by Elsevier B.V. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194546/
https://www.ncbi.nlm.nih.gov/pubmed/32251729
http://dx.doi.org/10.1016/j.hjc.2020.03.002
Descripción
Sumario:OBJECTIVE: Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. GRECCO-19 will be a prospective, randomized, open-labeled, controlled study to assess the effects of colchicine in COVID-19 complications prevention. METHODS: Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature >37.5 oC and at least two out of the: i. sustained coughing, ii. sustained throat pain, iii. Anosmia and/or ageusia, iv. fatigue/tiredness, v. PaO2<95 mmHg will be included. Patients will be randomised (1:1) in colchicine or control group. RESULTS: Trial results will be disseminated through peer-reviewed publications and conference presentations. CONCLUSION: GRECCO-19 trial aims to identify whether colchicine may positively intervene in the clinical course of COVID-19. (ClinicalTrials.gov Identifier: NCT04326790).

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