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The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design
OBJECTIVE: Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Hellenic Society of Cardiology. Publishing services by Elsevier B.V.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194546/ https://www.ncbi.nlm.nih.gov/pubmed/32251729 http://dx.doi.org/10.1016/j.hjc.2020.03.002 |
| _version_ | 1783528360080572416 |
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| author | Deftereos, Spyridon G. Siasos, Gerasimos Giannopoulos, Georgios Vrachatis, Dimitrios A. Angelidis, Christos Giotaki, Sotiria G. Gargalianos, Panagiotis Giamarellou, Helen Gogos, Charalampos Daikos, Georgios Lazanas, Marios Lagiou, Pagona Saroglou, Georgios Sipsas, Nikolaos Tsiodras, Sotirios Chatzigeorgiou, Dimitrios Moussas, Nikolaos Kotanidou, Anastasia Koulouris, Nikolaos Oikonomou, Evangelos Kaoukis, Andreas Kossyvakis, Charalampos Raisakis, Konstantinos Fountoulaki, Katerina Comis, Mihalis Tsiachris, Dimitrios Sarri, Eleni Theodorakis, Andreas Martinez-Dolz, Luis Sanz-Sánchez, Jorge Reimers, Bernhard Stefanini, Giulio G. Cleman, Michael Filippou, Dimitrios Olympios, Christoforos D. Pyrgakis, Vlasios N. Goudevenos, John Hahalis, George Kolettis, Theofilos M. Iliodromitis, Efstathios Tousoulis, Dimitrios Stefanadis, Christodoulos |
| author_facet | Deftereos, Spyridon G. Siasos, Gerasimos Giannopoulos, Georgios Vrachatis, Dimitrios A. Angelidis, Christos Giotaki, Sotiria G. Gargalianos, Panagiotis Giamarellou, Helen Gogos, Charalampos Daikos, Georgios Lazanas, Marios Lagiou, Pagona Saroglou, Georgios Sipsas, Nikolaos Tsiodras, Sotirios Chatzigeorgiou, Dimitrios Moussas, Nikolaos Kotanidou, Anastasia Koulouris, Nikolaos Oikonomou, Evangelos Kaoukis, Andreas Kossyvakis, Charalampos Raisakis, Konstantinos Fountoulaki, Katerina Comis, Mihalis Tsiachris, Dimitrios Sarri, Eleni Theodorakis, Andreas Martinez-Dolz, Luis Sanz-Sánchez, Jorge Reimers, Bernhard Stefanini, Giulio G. Cleman, Michael Filippou, Dimitrios Olympios, Christoforos D. Pyrgakis, Vlasios N. Goudevenos, John Hahalis, George Kolettis, Theofilos M. Iliodromitis, Efstathios Tousoulis, Dimitrios Stefanadis, Christodoulos |
| author_sort | Deftereos, Spyridon G. |
| collection | PubMed |
| description | OBJECTIVE: Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. GRECCO-19 will be a prospective, randomized, open-labeled, controlled study to assess the effects of colchicine in COVID-19 complications prevention. METHODS: Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature >37.5 oC and at least two out of the: i. sustained coughing, ii. sustained throat pain, iii. Anosmia and/or ageusia, iv. fatigue/tiredness, v. PaO2<95 mmHg will be included. Patients will be randomised (1:1) in colchicine or control group. RESULTS: Trial results will be disseminated through peer-reviewed publications and conference presentations. CONCLUSION: GRECCO-19 trial aims to identify whether colchicine may positively intervene in the clinical course of COVID-19. (ClinicalTrials.gov Identifier: NCT04326790). |
| format | Online Article Text |
| id | pubmed-7194546 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Hellenic Society of Cardiology. Publishing services by Elsevier B.V. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71945462020-05-02 The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design Deftereos, Spyridon G. Siasos, Gerasimos Giannopoulos, Georgios Vrachatis, Dimitrios A. Angelidis, Christos Giotaki, Sotiria G. Gargalianos, Panagiotis Giamarellou, Helen Gogos, Charalampos Daikos, Georgios Lazanas, Marios Lagiou, Pagona Saroglou, Georgios Sipsas, Nikolaos Tsiodras, Sotirios Chatzigeorgiou, Dimitrios Moussas, Nikolaos Kotanidou, Anastasia Koulouris, Nikolaos Oikonomou, Evangelos Kaoukis, Andreas Kossyvakis, Charalampos Raisakis, Konstantinos Fountoulaki, Katerina Comis, Mihalis Tsiachris, Dimitrios Sarri, Eleni Theodorakis, Andreas Martinez-Dolz, Luis Sanz-Sánchez, Jorge Reimers, Bernhard Stefanini, Giulio G. Cleman, Michael Filippou, Dimitrios Olympios, Christoforos D. Pyrgakis, Vlasios N. Goudevenos, John Hahalis, George Kolettis, Theofilos M. Iliodromitis, Efstathios Tousoulis, Dimitrios Stefanadis, Christodoulos Hellenic J Cardiol Article OBJECTIVE: Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. GRECCO-19 will be a prospective, randomized, open-labeled, controlled study to assess the effects of colchicine in COVID-19 complications prevention. METHODS: Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature >37.5 oC and at least two out of the: i. sustained coughing, ii. sustained throat pain, iii. Anosmia and/or ageusia, iv. fatigue/tiredness, v. PaO2<95 mmHg will be included. Patients will be randomised (1:1) in colchicine or control group. RESULTS: Trial results will be disseminated through peer-reviewed publications and conference presentations. CONCLUSION: GRECCO-19 trial aims to identify whether colchicine may positively intervene in the clinical course of COVID-19. (ClinicalTrials.gov Identifier: NCT04326790). Hellenic Society of Cardiology. Publishing services by Elsevier B.V. 2020 2020-04-03 /pmc/articles/PMC7194546/ /pubmed/32251729 http://dx.doi.org/10.1016/j.hjc.2020.03.002 Text en © 2020 Hellenic Society of Cardiology. Publishing services by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Article Deftereos, Spyridon G. Siasos, Gerasimos Giannopoulos, Georgios Vrachatis, Dimitrios A. Angelidis, Christos Giotaki, Sotiria G. Gargalianos, Panagiotis Giamarellou, Helen Gogos, Charalampos Daikos, Georgios Lazanas, Marios Lagiou, Pagona Saroglou, Georgios Sipsas, Nikolaos Tsiodras, Sotirios Chatzigeorgiou, Dimitrios Moussas, Nikolaos Kotanidou, Anastasia Koulouris, Nikolaos Oikonomou, Evangelos Kaoukis, Andreas Kossyvakis, Charalampos Raisakis, Konstantinos Fountoulaki, Katerina Comis, Mihalis Tsiachris, Dimitrios Sarri, Eleni Theodorakis, Andreas Martinez-Dolz, Luis Sanz-Sánchez, Jorge Reimers, Bernhard Stefanini, Giulio G. Cleman, Michael Filippou, Dimitrios Olympios, Christoforos D. Pyrgakis, Vlasios N. Goudevenos, John Hahalis, George Kolettis, Theofilos M. Iliodromitis, Efstathios Tousoulis, Dimitrios Stefanadis, Christodoulos The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design |
| title | The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design |
| title_full | The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design |
| title_fullStr | The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design |
| title_full_unstemmed | The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design |
| title_short | The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design |
| title_sort | greek study in the effects of colchicine in covid-19 complications prevention (grecco-19 study): rationale and study design |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194546/ https://www.ncbi.nlm.nih.gov/pubmed/32251729 http://dx.doi.org/10.1016/j.hjc.2020.03.002 |
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