The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

Cytokine storm is a general term applied to maladaptive cytokine release in response to infection and other stimuli. The pathogenesis is complex but includes loss of regulatory control of proinflammatory cytokine production, both at local and systemic levels. The disease progresses rapidly, and the...

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Detalles Bibliográficos
Autores principales: Ye, Qing, Wang, Bili, Mao, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Infection Association. Published by Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194613/
https://www.ncbi.nlm.nih.gov/pubmed/32283152
http://dx.doi.org/10.1016/j.jinf.2020.03.037
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author Ye, Qing
Wang, Bili
Mao, Jianhua
author_facet Ye, Qing
Wang, Bili
Mao, Jianhua
author_sort Ye, Qing
collection PubMed
description Cytokine storm is a general term applied to maladaptive cytokine release in response to infection and other stimuli. The pathogenesis is complex but includes loss of regulatory control of proinflammatory cytokine production, both at local and systemic levels. The disease progresses rapidly, and the mortality is high. Some evidence shows that, during the coronavirus disease 2019 (COVID-19) epidemic, severe deterioration in some patients has been closely associated with dysregulated and excessive cytokine release. This article reviews what we know of the mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm in an attempt to provide some background to inform future guidance for clinical treatment.
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spelling pubmed-71946132020-05-02 The pathogenesis and treatment of the `Cytokine Storm' in COVID-19 Ye, Qing Wang, Bili Mao, Jianhua J Infect Article Cytokine storm is a general term applied to maladaptive cytokine release in response to infection and other stimuli. The pathogenesis is complex but includes loss of regulatory control of proinflammatory cytokine production, both at local and systemic levels. The disease progresses rapidly, and the mortality is high. Some evidence shows that, during the coronavirus disease 2019 (COVID-19) epidemic, severe deterioration in some patients has been closely associated with dysregulated and excessive cytokine release. This article reviews what we know of the mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm in an attempt to provide some background to inform future guidance for clinical treatment. The British Infection Association. Published by Elsevier Ltd. 2020-06 2020-04-10 /pmc/articles/PMC7194613/ /pubmed/32283152 http://dx.doi.org/10.1016/j.jinf.2020.03.037 Text en © 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ye, Qing
Wang, Bili
Mao, Jianhua
The pathogenesis and treatment of the `Cytokine Storm' in COVID-19
title The pathogenesis and treatment of the `Cytokine Storm' in COVID-19
title_full The pathogenesis and treatment of the `Cytokine Storm' in COVID-19
title_fullStr The pathogenesis and treatment of the `Cytokine Storm' in COVID-19
title_full_unstemmed The pathogenesis and treatment of the `Cytokine Storm' in COVID-19
title_short The pathogenesis and treatment of the `Cytokine Storm' in COVID-19
title_sort pathogenesis and treatment of the `cytokine storm' in covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194613/
https://www.ncbi.nlm.nih.gov/pubmed/32283152
http://dx.doi.org/10.1016/j.jinf.2020.03.037
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