Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock

We report the case of an 88-year-old man with coronavirus disease 2019 (COVID-19) who presented with ARDS and septic shock. The patient had exquisite BP sensitivity to low-dose angiotensin II (Ang-2), allowing for rapid liberation from high-dose vasopressors. We hypothesize that sensitivity to Ang-2...

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Autores principales: Wang, Hanyin, Das, Subhraleena, Wieruszewski, Patrick M., Taji, Jamil, Bartlett, Brian, Azad, Nabila, Chowdhury, Arnab, Kolar, Gururaj J., Jain, Nitesh, Subla, Mir R., Khan, Syed Anjum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Chest Physicians. Published by Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194656/
https://www.ncbi.nlm.nih.gov/pubmed/32335068
http://dx.doi.org/10.1016/j.chest.2020.04.015
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author Wang, Hanyin
Das, Subhraleena
Wieruszewski, Patrick M.
Taji, Jamil
Bartlett, Brian
Azad, Nabila
Chowdhury, Arnab
Kolar, Gururaj J.
Jain, Nitesh
Subla, Mir R.
Khan, Syed Anjum
author_facet Wang, Hanyin
Das, Subhraleena
Wieruszewski, Patrick M.
Taji, Jamil
Bartlett, Brian
Azad, Nabila
Chowdhury, Arnab
Kolar, Gururaj J.
Jain, Nitesh
Subla, Mir R.
Khan, Syed Anjum
author_sort Wang, Hanyin
collection PubMed
description We report the case of an 88-year-old man with coronavirus disease 2019 (COVID-19) who presented with ARDS and septic shock. The patient had exquisite BP sensitivity to low-dose angiotensin II (Ang-2), allowing for rapid liberation from high-dose vasopressors. We hypothesize that sensitivity to Ang-2 might be related to biological effect of severe acute respiratory syndrome coronavirus 2 infection. The case is suggestive of a potential role for synthetic Ang-2 for patients with COVID-19 and septic shock. Further studies are needed to confirm our observed clinical efficacy.
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spelling pubmed-71946562020-05-02 Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock Wang, Hanyin Das, Subhraleena Wieruszewski, Patrick M. Taji, Jamil Bartlett, Brian Azad, Nabila Chowdhury, Arnab Kolar, Gururaj J. Jain, Nitesh Subla, Mir R. Khan, Syed Anjum Chest Article We report the case of an 88-year-old man with coronavirus disease 2019 (COVID-19) who presented with ARDS and septic shock. The patient had exquisite BP sensitivity to low-dose angiotensin II (Ang-2), allowing for rapid liberation from high-dose vasopressors. We hypothesize that sensitivity to Ang-2 might be related to biological effect of severe acute respiratory syndrome coronavirus 2 infection. The case is suggestive of a potential role for synthetic Ang-2 for patients with COVID-19 and septic shock. Further studies are needed to confirm our observed clinical efficacy. American College of Chest Physicians. Published by Elsevier Inc. 2020-08 2020-04-23 /pmc/articles/PMC7194656/ /pubmed/32335068 http://dx.doi.org/10.1016/j.chest.2020.04.015 Text en © 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Wang, Hanyin
Das, Subhraleena
Wieruszewski, Patrick M.
Taji, Jamil
Bartlett, Brian
Azad, Nabila
Chowdhury, Arnab
Kolar, Gururaj J.
Jain, Nitesh
Subla, Mir R.
Khan, Syed Anjum
Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock
title Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock
title_full Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock
title_fullStr Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock
title_full_unstemmed Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock
title_short Unexpected BP Sensitivity to Angiotensin II in a Patient With Coronavirus Disease 2019, ARDS, and Septic Shock
title_sort unexpected bp sensitivity to angiotensin ii in a patient with coronavirus disease 2019, ards, and septic shock
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194656/
https://www.ncbi.nlm.nih.gov/pubmed/32335068
http://dx.doi.org/10.1016/j.chest.2020.04.015
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