Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?

SARS-CoV-2 is a novel virus of the Coronaviridiae family that represents a major global health issue. Mechanisms implicated in virus/host cells interaction are central for cell infection and replication that in turn lead to disease onset and local damage. To enter airway and lung epithelia, SARS-CoV...

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Autores principales: Perrotta, Fabio, Matera, Maria Gabriella, Cazzola, Mario, Bianco, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194970/
https://www.ncbi.nlm.nih.gov/pubmed/32364961
http://dx.doi.org/10.1016/j.rmed.2020.105996
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author Perrotta, Fabio
Matera, Maria Gabriella
Cazzola, Mario
Bianco, Andrea
author_facet Perrotta, Fabio
Matera, Maria Gabriella
Cazzola, Mario
Bianco, Andrea
author_sort Perrotta, Fabio
collection PubMed
description SARS-CoV-2 is a novel virus of the Coronaviridiae family that represents a major global health issue. Mechanisms implicated in virus/host cells interaction are central for cell infection and replication that in turn lead to disease onset and local damage. To enter airway and lung epithelia, SARS-CoV-2 attaches to ACE2 receptors by spike (S) glycoproteins. Molecular mechanisms that promote interaction between SARS-CoV-2 virus and host with particular focus on virus cell entry receptor ACE2 are described. We further explore the impact of underlying medical conditions and therapies including renin-angiotensin inhibitors on modulating ACE 2, which is the major SARS-CoV-2 cell entry receptor.
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spelling pubmed-71949702020-05-02 Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter? Perrotta, Fabio Matera, Maria Gabriella Cazzola, Mario Bianco, Andrea Respir Med Review Article SARS-CoV-2 is a novel virus of the Coronaviridiae family that represents a major global health issue. Mechanisms implicated in virus/host cells interaction are central for cell infection and replication that in turn lead to disease onset and local damage. To enter airway and lung epithelia, SARS-CoV-2 attaches to ACE2 receptors by spike (S) glycoproteins. Molecular mechanisms that promote interaction between SARS-CoV-2 virus and host with particular focus on virus cell entry receptor ACE2 are described. We further explore the impact of underlying medical conditions and therapies including renin-angiotensin inhibitors on modulating ACE 2, which is the major SARS-CoV-2 cell entry receptor. Published by Elsevier Ltd. 2020-07 2020-04-25 /pmc/articles/PMC7194970/ /pubmed/32364961 http://dx.doi.org/10.1016/j.rmed.2020.105996 Text en © 2020 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review Article
Perrotta, Fabio
Matera, Maria Gabriella
Cazzola, Mario
Bianco, Andrea
Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?
title Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?
title_full Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?
title_fullStr Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?
title_full_unstemmed Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?
title_short Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?
title_sort severe respiratory sars-cov2 infection: does ace2 receptor matter?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194970/
https://www.ncbi.nlm.nih.gov/pubmed/32364961
http://dx.doi.org/10.1016/j.rmed.2020.105996
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