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Coronavirus membrane fusion mechanism offers a potential target for antiviral development
The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the need to develop effective therapies against the causative agent, SARS-CoV-2, and also against other pathogenic coronaviruses (CoV) that have emerged in the past or might appear in future. Researchers are therefore focusing...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194977/ https://www.ncbi.nlm.nih.gov/pubmed/32272173 http://dx.doi.org/10.1016/j.antiviral.2020.104792 |
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author | Tang, Tiffany Bidon, Miya Jaimes, Javier A. Whittaker, Gary R. Daniel, Susan |
author_facet | Tang, Tiffany Bidon, Miya Jaimes, Javier A. Whittaker, Gary R. Daniel, Susan |
author_sort | Tang, Tiffany |
collection | PubMed |
description | The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the need to develop effective therapies against the causative agent, SARS-CoV-2, and also against other pathogenic coronaviruses (CoV) that have emerged in the past or might appear in future. Researchers are therefore focusing on steps in the CoV replication cycle that may be vulnerable to inhibition by broad-spectrum or specific antiviral agents. The conserved nature of the fusion domain and mechanism across the CoV family make it a valuable target to elucidate and develop pan-CoV therapeutics. In this article, we review the role of the CoV spike protein in mediating fusion of the viral and host cell membranes, summarizing the results of research on SARS-CoV, MERS-CoV, and recent peer-reviewed studies of SARS-CoV-2, and suggest that the fusion mechanism be investigated as a potential antiviral target. We also provide a supplemental file containing background information on the biology, epidemiology, and clinical features of all human-infecting coronaviruses, along with a phylogenetic tree of these coronaviruses. |
format | Online Article Text |
id | pubmed-7194977 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71949772020-05-02 Coronavirus membrane fusion mechanism offers a potential target for antiviral development Tang, Tiffany Bidon, Miya Jaimes, Javier A. Whittaker, Gary R. Daniel, Susan Antiviral Res Article The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the need to develop effective therapies against the causative agent, SARS-CoV-2, and also against other pathogenic coronaviruses (CoV) that have emerged in the past or might appear in future. Researchers are therefore focusing on steps in the CoV replication cycle that may be vulnerable to inhibition by broad-spectrum or specific antiviral agents. The conserved nature of the fusion domain and mechanism across the CoV family make it a valuable target to elucidate and develop pan-CoV therapeutics. In this article, we review the role of the CoV spike protein in mediating fusion of the viral and host cell membranes, summarizing the results of research on SARS-CoV, MERS-CoV, and recent peer-reviewed studies of SARS-CoV-2, and suggest that the fusion mechanism be investigated as a potential antiviral target. We also provide a supplemental file containing background information on the biology, epidemiology, and clinical features of all human-infecting coronaviruses, along with a phylogenetic tree of these coronaviruses. Elsevier B.V. 2020-06 2020-04-06 /pmc/articles/PMC7194977/ /pubmed/32272173 http://dx.doi.org/10.1016/j.antiviral.2020.104792 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Tang, Tiffany Bidon, Miya Jaimes, Javier A. Whittaker, Gary R. Daniel, Susan Coronavirus membrane fusion mechanism offers a potential target for antiviral development |
title | Coronavirus membrane fusion mechanism offers a potential target for antiviral development |
title_full | Coronavirus membrane fusion mechanism offers a potential target for antiviral development |
title_fullStr | Coronavirus membrane fusion mechanism offers a potential target for antiviral development |
title_full_unstemmed | Coronavirus membrane fusion mechanism offers a potential target for antiviral development |
title_short | Coronavirus membrane fusion mechanism offers a potential target for antiviral development |
title_sort | coronavirus membrane fusion mechanism offers a potential target for antiviral development |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194977/ https://www.ncbi.nlm.nih.gov/pubmed/32272173 http://dx.doi.org/10.1016/j.antiviral.2020.104792 |
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